The Value of Enhanced CT Scanning Combined with Exosome LncRNA RP5-977B1 in the Diagnosis and Prognosis of Non-small Cell Lung Cancer
Objective To evaluate the diagnostic and prognostic value of enhanced CT scan combined with long chain noncoding RNA(LncRNA)RP5-977B1 in non-small cell lung cancer(NSCLC).Methods Eighty patients with NSCLC admitted in our hospital from May 2018 to May 2019 were selected as NSCLC group,and another 80 patients with benign lung diseases admitted in the same period were selected as control group.All patients were given CT enhanced scanning to obtain peak enhancement(PH),peak enhancement time(Tp)and perfusion value.The expression of LncRNA RP5-977B1 was detected by real-time polymerase chain reaction(RT-PCR).Patients with NSCLC were followed up for 3 years in an outpatient or telephone setting.The last follow-up was on May 31,2022,and the patients were divided into survival group(n=49)and death group(n=31).Receiver operating curve(ROC)was used to analyze the diagnostic and prognostic value of enhanced CT combined with LncRNA RP5-977B1 in NSCLC.Results Compared with the control group,the PH,Tp,perfusion value and LncRNA RP5-977B1 expression level in NSCLC group were significantly higher(P＜0.05).ROC curve showed that CT enhanced scanning parameters combined with LncRNA RP5-977B1 had the highest diagnostic efficiency for NSCLC,AUC was 0.929;Compared with death group,PH,Tp,perfusion value and expression level of LncRNA RP5-977B1 in survival group were significantly lower(P＜0.05).ROC curve showed that CT enhanced scanning parameters combined with LncRNA RP5-977B1 had the highest efficacy in evaluating prognosis of NSCLC patients,with AUC of 0.925.Conclusion Enhanced CT scan parameters and LncRNA RP5-977B1 expression level are significantly elevated in NSCLC patients,and their combination has a high value in the diagnosis of NSCLC and the prognosis of patients.
万方数据
维普
