The Values of Dynamic Contrast Enhancement Magnetic Resonance Imaging and Intravoxel Incoherent Motion to the Diagnosis of Triple Negative Breast Cancer
Objective To investigate predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and intravoxel incoherent motion(IVIM)for the diagnosis of triple negative breast cancer.Methods A total of 180 cases of breast cancer patients confirmed by pathology were collected,including 49 cases in the triple negative(TNBC)group and 131 cases in the non-TNBC group.DCE-MRI and IVIM scanning were performed in all patients.The clinicopathological characteristics and conventional MRI features and the quantitative parameters of IVIM and DCE-MRI models were analyzed.Results The Ve value of the TNBC group was lower than that of the non-TNBC group(P＜0.001),showing a low degree of negative correlation(r=-0.439,P＜0.001).The D,f and Kep values of the TNBC group were higher than those of the non-TNBC group(P=0.002～0.016),showing a low degree of positive correlation(r=0.186～0.257,P＜0.05).There was no statistical difference in D*and Ktrans values between the two groups(P＞0.05).D≥0.86×10-3mm2/s,f≥38.1％,Kep≥0.359/min,Ve≤0.589 are independent influencing factors for the identification of TNBC and non-TNBC.The AUC of Ve value was 0.784,which was higher than other quantitative factors(Z=2.201～2.752,P=0.006～0.028).The AUC of the DCE-MRI model was 0.817,which was greater than that of the IVIM model(AUC=0.657)and conventional MRI model(AUC=0.689),the difference was statistically significant(Z=2.657,P=0.008;Z=2.516,P=0.012).The AUC of the combining IVIM and DCE-MRI models was 0.862,the diagnostic performance was higher than the single model(Z=2.194～4.649,P＜0.05),the sensitivity was 83.7％,the specificity was 74.8％,and the accuracy was 80.0％.Conclusion DCE-MRI and IVIM models can be used for the diagnosis of TNBC.Among them,the Ve value of DCE-MRI model has the highest diagnostic efficiency.The diagnostic efficiency of DCE-MRI combined with IVIM model to differentiate TNBC and non-TNBC is better than that of a single model.
Breast NeoplasmsTriple NegativeMagnetic Resonance ImagingIntravoxel Incoherent MotionDynamic Contrast Enhancement Magnetic Resonance Imaging
万方数据
维普
