DCE-MRI Imaging Features of Preoperative Distinguish Three Negative and Three Negative Breast Cancer and Its Correlation with EGFR Expression Research
Objective To investigate the diagnostic value of DCE-MRI characteristics,peritumoral and intratumoral ADC values,peritumor edema and preoperative angiogenesis to distinguish triple-negative breast cancer(TNBC)from non-triple-negative breast cancer(nTNBC)and their correlation with EGFR expression.Methods A retrospective analysis was performed for 146 cases of breast cancer diagnosed by surgical pathology in Gansu Maternal and Child Health Care Hospital,and divided into TNBC group and nTNBC group,and the differences in general clinical data,MRI characteristics,peritumor and intratumoral ADC values,peritumor edema,angiogenesis and EGFR expression between the two groups were compared.Results Compared with the nTNBC group,TNBC was usually round,with smooth edges,ring strengthening,peritumor edema,increased angiogenesis,and high EGFR expression,and there was a significant significance between the two groups(P＜0.05).Peritumoral ADCmean[(1.21±0.18)×10-3mm2/s)],intratumoral ADCmean[(0.79±0.15)×10-3mm2/s)],intratumoral ADCmax[(0.95±0.19)×10-3mm2/s)]and intratumoral ADCmin[(0.63±0.04)×10-3mm2/s)]in the TNBC group were smaller than the peritumoral ADCmean[(1.24±]in the nTNBC group0.34)×10-3mm2/s)],intratumoral ADCmean[(0.91±0.28)×10-3mm2/s)],intratumoral ADCmax[(1.06±0.32)×10-3mm2/s)]]and intratumoral ADCmin[(0.78±0.02)×10-3mm2/s)],There were significant differences between intratumoral ADCmean and intratumoral ADCmin(P＜0.05),while the difference between peritumoral ADCmean and intratumoral ADCmax was not statistically significant.Conclusion Quantitative analysis of peritumor and intratumoral ADC,tumor morphology,internal enhancement mode,peritumor edema and angiogenesis can be used as the imaging basis for preoperative evaluation of TNBC,and high EGFR expression in TNBC is associated with poor prognosis.
Triple-negative Breast CancerNon-triple-negative Breast CancerEGFR
万方数据
维普
