Application of Contrast-enhanced Ultrasound Combined with NLR in Breast Cancer with Lymph Node Metastasis
Objective To analyze the value of contrast-enhanced ultrasound combined with neutrophil lymphocyte ratio(NLR)in the evaluation of breast cancer with lymph node metastasis.Methods 99 patients with breast cancer who were treated in our hospital from January 2020 to September 2022 were selected as the study subjects,and they were examined by contrast-enhanced ultrasound and blood routine examination.Based on the pathological diagnosis results after surgery,they were divided into metastasis group(n=57)and non metastasis group(n=42)according to whether they had lymph node metastasis.The contrast-enhanced ultrasound parameters and peripheral blood NLR levels were compared between the metastatic group and the non metastatic group.Pearson correlation analysis was used to analyze the correlation between the contrast-enhanced ultrasound parameters and peripheral blood NLR levels and the number of lymph node metastases.The evaluation value of contrast-enhanced ultrasound parameters and peripheral blood NLR on breast cancer with lymph node metastasis was evaluated by receiver operating characteristic curve(ROC).Results There was no significant difference in the arrival time(AT),peak time(TTP)and peak intensity(PI)between the metastatic group and the non-metastatic group(P＞0.05);The difference between high and low perfusion areas in lymph node parenchyma(SImax-SImin)and the level of NLR in peripheral blood in metastatic group were higher than those in non-metastatic group(P＜0.05);The levels of SImax-SIMin and NLR were positively correlated with the number of lymph node metastasis(r=0.467,0.395,P＜0.05).The ROC results showed the area under the ROC curve(AUC)of SImax SImin,NLR and their combined assessment of breast cancer with lymph node metastasis were 0.964,0.731 and 0.982 respectively,the critical values were 24.96 and 2.37 respectively,the sensitivity was 84.21％,64.91％and 85.96％respectively,and the specificity was 92.86％,69.05％and 100.00％respectively.The combined assessment efficiency was significantly better than that of each indicator evaluated alone.Conclusion Contrast enhanced ultrasonography and peripheral blood NLR level detection have certain evaluation value for breast cancer with lymph node metastasis,and their combined evaluation is more effective.
Breast CancerLymph Node MetastasisContrast-enhanced UltrasoundNeutrophil to Lymphocyte RatioAppraisal Value
万方数据
维普
