Imaging Findings of DCE-MRI and DWI in Patients with Prostate Cancer and Their Relationship with PSA
Objective To explore the imaging findings of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)and diffusion-weighted imaging(DWI)and thir relationship with prostate-specific antigen(PSA)in patients with prostate cancer(PCa).Methods 78 patients with suspected PCa admitted to our hospital from October 2020 to June 2023 were examined by DCE-MRI and DWI,and were divided into two groups according to pathological biopsy results,including 45 cases with prostatic hyperplasia and 33 cases with PCa.The diagnostic results of DCE-MRI and DWI sequences were analyzed,and the dynamic enhanced scan parameters and the total prostate-specific antigen(tPSA)and free prostate-specific antigen(fPSA)levels were compared between the two groups.Results DCE-MRI images showed that the lesions of PCa patients were visible on T2WI,and the early part of enhanced scan was enhanced.DWI images showed slightly higher signals and had a smaller ADC.Dynamic enhancement curve presented an outflow pattern.In addition,a large area of T2-FLAIR low signal was observed in the left transition zone and both sides of the peripheral zone,and the boundary was unclear.DWI images show limited diffusion and low ADC signals.Ktrans,Kep and Ve in PCa group were higher than those in prostatic hyperplasia group while ADC was lower than that in prostatic hyperplasia group(P＜0.05).The tPSA and fPSA in PCa group were higher while the fPSA/tPSA ratio was lower than that in prostatic hyperplasia group(P＜0.05).Ktrans,Kep and Ve were negatively correlated with fPSA/tPSA ratio(r=-0.551,-0.566,-0.573,P＜0.05),and ADC was positively correlated with fPSA/tPSA ratio(r=0.575,P＜0.05).Conclusion There are differences in magnetic resonance imaging characteristics between prostatic hyperplasia and malignant tumors.Imaging parameters are closely related to PSA in tumor patients.DCE-MRI and DWI can accurately assist the diagnosis of PCa.
Prostate CancerDynamic Contrast-enhanced Magnetic Resonance ImagingDiffusion-weighted ImagingProstate-specific Antigen
万方数据
维普
