The Dosimetry Advantage of BMS-IMRT and Three-dimensional Conformal Radiation Therapy in Postoperative Radiotherapy of Cervical Cancer and Their Effects on Organs at Risk
Objective To compare the dosimetry differences between bone marrow-sparing intensity modulated radiation therapy(BMS-IMRT)and three-dimensional conformal radiation therapy(3D-CRT)in total pelvic radiotherapy after cervical cancer surgery,and to explore the effects on organs at risk(OARs).Methods A retrospective analysis was performed on the clinical case data of 40 patients undergoing total pelvic radiotherapy after cervical cancer surgery who were admitted to the hospital from August 2018 to August 2020.According to different postoperative radiotherapy methods,they were divided into BMS-IMRT group(n=16,BMS-IMRT)and 3D-CRT group(n=24,3D-CRT).The target dose distribution,dosimetry differences of OARs and bone marrow suppression between the two groups were compared.Results There was no significant difference in D95[(44.78±0.42)vs(44.61±0.57)]and V95[(99.40±2.73)vs(99.07±5.26)]between BMS-IMRT group and 3D-CRT group(P＞0.05).The homogeneity index(HI)[(1.07±0.04)vs(1.11±0.02)]and conformal index(Cl)[(0.67±0.10)vs(0.48±0.07)]in BMS-IMRT group were better than those in 3D-CRT group(P＜0.05).V40 of rectum,bladder and small intestine,V35 of small intestine,V20 and V10 of bone marrow in 3D-CRT group were significantly higher than those in BMS-IMRT group(P＜0.05).The proportion of cases with bone marrow suppression at grade Ⅱ and above in BMS-IMRT group was significantly lower than that in 3D-CRT group[66.67％vs 31.25％](P＜0.05).Conclusion In total pelvic radiotherapy after cervical cancer surgery,BMS-IMRT is more beneficial to protect OARs and improve bone marrow suppression under the premise of ensuring the target dose.
万方数据
维普
