The Value of DCE-MRI and Tumor Markers for the Assessment of Lymph Node Metastasis in Rectal Cancer
Objective To investigate the value of dynamic enhanced magnetic resonance imaging(DCE-MRI)and tumor markers for the assessment of lymph node metastasis in rectal cancer.Methods Prospectively,180 patients with rectal cancer treated by surgical resection admitted to our hospital from January 2019 to December 2022 were selected for the study.Patients were divided into lymphatic metastasis group and no lymphatic metastasis group according to their lymph node metastasis,46 and 134 cases each,and the differences in DCE-MRI parameters[transit constant(Ktrans),rate constant(Kep),volume fraction(Ve)],tumor marker levels[serum carcinoembryonic antigen(CEA)and glycoantigen 199(CA199)]between lymphatic metastasis group and no lymph node metastasis group were compared.Factors associated with lymph node metastasis were analyzed by binary logistic regression,and the value of DCE-MRI parameters(Ktrans,Ve,Kep),tumor marker levels(CEA,CA199)with combined data was evaluated by subject operating characteristic curve(ROC).Results Ktrans,Ve,and Kep were higher in the lymphatic metastasis group than in the group without lymph node metastasis(P＜0.05).CEA and CA199 levels were higher in the lymphatic metastasis group than in the no lymph node metastasis group(P＜0.05).Binary logistic regression analysis showed that Ktrans,Ve,Kep,CEA,and CA199 were factors influencing lymph node metastasis(P＜0.05).ROC analysis showed that the AUCs of Ktrans,Ve,Kep,CEA,and CA199 for assessing lymph node metastasis were 0.762,0.813,0.808,0.763,and 0.754.the AUCs of combined DCE-MRI parameters,combined tumor markers,and combined five items to assess lymph node metastasis were 0.889,0.853,and 0.895,respectively.Conclusion The quantitative parameters of DCE-MRI,CEA and CA199 have good value in assessing lymph node metastasis,and the combined test has better accuracy in assessing lymph node metastasis,which can provide a basis for clinical treatment.
Rectal CancerLymph Node MetastasisDynamic Enhanced Magnetic Resonance ImagingTumor MarkersAssessment Value
万方数据
维普
