Change Characteristics of Magnetic Resonance Imaging Parameters in Multiple Myeloma before and after Induction Chemotherapy
Objectie To explore the change characteristics of magnetic resonance imaging parameters in multiple myeloma(MM)before and after induction chemotherapy.Methods A total of 118 patients with MM undergoing chemotherapy in the hospital were enrolled between January 2021 and January 2023.After 4 courses of chemotherapy,the chemotherapy effect in the two groups was evaluated.According to Chinese guidelines for the diagnosis and treatment of multiple myeloma,patients were divided into remission group(n=45)and non-remission group(n=73).Before chemotherapy,after 2 and 4 courses of chemotherapy,all underwent magnetic resonance examination and detection of serum immunoglobulin(M protein).The changes of magnetic resonance imaging parameters and M protein before and after chemotherapy were compared between the two groups.The correlation between the mean values of apparent diffusion coefficient(ADC)and M protein before and after chemotherapy was analyzed by Pearson correlation analysis,and the diagnostic value of M protein and mean value of ADC for chemotherapy effect was analyzed by receiver operating characteristic(ROC)curves.Results After chemotherapy,M protein and mean value of ADC were decreased,and which were lower in remission group than non-remission group before and after chemotherapy(P＜0.05).Pearson correlation analysis showed that mean value of ADC before and after chemotherapy was positively correlated with M protein in MM patients(P＜0.05).ROC curves analysis showed that AUC,sensitivity and specificity of M protein and mean value of ADC before chemotherapy for predicting chemotherapy effect were(0.808,0.664),(93.20％,78.10％)and(24.40％,44.40％),respectively.Conclusion With the extension of chemotherapy cycle,magnetic resonance imaging parameters and serum M protein increase in patients with multiple myeloma.Clinical,ADC value and serum M protein can be applied to predict chemotherapy effect.
万方数据
维普
