Correlational Study on the Morphological Features of MRI and the Expression of MGMT Protein in Adult-type Diffuse Glioma
Objective To explore the correlation between morphological manifestations of magnetic resonance imaging(MRI)and the expression of MGMT protein in adult-type diffuse glioma.Methods The preoperative MRI and clinical data of 219 patients with diffuse glioma in the Affiliated Hospital of Xuzhou Medical University were analyzed retrospectively.According to the expression of MGMT protein,these patients were divided into two groups:positive and negative MGMT protein expression,and the differences in the image morphological characteristics and clinical features between the two groups were analyzed.Results Compared with gliomas with negative MGMT protein expression,gliomas with positive MGMT protein expression were more common with ring enhancement,moderate to severe peritumoral edema and high-grade tumors(WHO Ⅲ-Ⅳ)(P＜0.005).Condusion Adult-type diffuse gliomas with positive MGMT protein expression are characterized by ring enhancement and moderate to severe peritumoral edema on MRI.These imaging features are helpful for early prediction of MGMT protein expression and provide assistance for clinical treatment.
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