成人型弥漫性脑胶质瘤影像形态学表现与MGMT蛋白表达情况的相关性研究
Correlational Study on the Morphological Features of MRI and the Expression of MGMT Protein in Adult-type Diffuse Glioma
段瑾 1葛学 1卓铄 1汪秀玲 1许倩1
作者信息
- 1. 徐州医科大学附属医院影像科(江苏徐州 221000)
- 折叠
摘要
目的 研究成人型弥漫性脑胶质瘤的MRI影像表现与MGMT蛋白表达情况的相关性.方法 回顾性分析徐州医科大学附属医院219例成人型弥漫性胶质瘤患者术前磁共振影像学及一般临床资料,根据MGMT蛋白表达情况将其分为MGMT蛋白表达阳性与阴性两组,分析两组间的影像形态学特征及临床特点之间的差异.结果 与MGMT蛋白表达阴性的胶质瘤相比,MGMT蛋白表达阳性的胶质瘤磁共振增强以环形强化更为多见,瘤周水肿程度以中重度水肿多见,高级别(WHOⅢ-Ⅳ级)肿瘤占据多数(P＜0.005).结论 MGMT蛋白表达阳性的成人型弥漫性胶质瘤在磁共振图像上以环形强化、瘤周水肿程度较重为特点,这些影像特征有助于早期预知MGMT蛋白表达情况,对临床治疗提供帮助.
Abstract
Objective To explore the correlation between morphological manifestations of magnetic resonance imaging(MRI)and the expression of MGMT protein in adult-type diffuse glioma.Methods The preoperative MRI and clinical data of 219 patients with diffuse glioma in the Affiliated Hospital of Xuzhou Medical University were analyzed retrospectively.According to the expression of MGMT protein,these patients were divided into two groups:positive and negative MGMT protein expression,and the differences in the image morphological characteristics and clinical features between the two groups were analyzed.Results Compared with gliomas with negative MGMT protein expression,gliomas with positive MGMT protein expression were more common with ring enhancement,moderate to severe peritumoral edema and high-grade tumors(WHO Ⅲ-Ⅳ)(P＜0.005).Condusion Adult-type diffuse gliomas with positive MGMT protein expression are characterized by ring enhancement and moderate to severe peritumoral edema on MRI.These imaging features are helpful for early prediction of MGMT protein expression and provide assistance for clinical treatment.
关键词
胶质细胞瘤/MGMT启动子甲基化/MGMT蛋白/磁共振成像/瘤周水肿Key words
Glioma/MGMT Promoter Methylation/MGMT Protein/Magnetic Resonance imaging/Peritumoral Edema引用本文复制引用
基金项目
徐州市科技局课题资助项目(KC23259)
出版年
2024
NETL
NSTL
万方数据