Clinical Imaging and Prognosis Analysis of Pituitary Blastoma
Objective Toinvestigate the clinical characteristics,imaging features and prognosis of pituitary blastoma(PitB).Methods The clinical and imaging characteristics of a case of PitB were studied.Medical literature was searched with the keywords of"pituitary blastoma"in PubMed,China National Knowledge Infrastructure and Wanfang database.Combined with the case,the clinical and imaging findings of the PitB children were summarized and the prognosis was analyzed.Results A total of 23 patients with PitB were collected.The most common clinical manifestations were Cushing syndrome,neuro-ophthalmopathy,developmental delay.PitB mainly manifested as a sellar and suprasellar solid,solid-cystic or cystic mass,and the solid part of the tumor showed obvious enhancement.Except for case 22,13 patients survived and 9 died at the last follow-up.The 5-year overall survival(OS)rate was(58±11)％1.The 5-year OS rates of total/near-total resection and subtotal/non resection group were(79±13)％and(42±14)％,respectively.7/23 patients received chemotherapy or chemoradiotherapy.The 5-year OS rates of patients with chemoradiotherapy and without chemoradiotherapy were(44±13)％and(86±13)％,respectively.Log-rank test showed that the 5-year OS of total/near-total resection group was higher than that in subtotal/non-resection group(x2=4.705,P=0.030),the differences were statistically significant.While chemoradiotherapy had no statistical significance on OS(x2=1.554,P=0.213).Conclusion The most common clinical manifestations of PitB were Cushing's syndrome,neuro-ophthalmopathy,and developmental delay.Radiologically,PitBs usually manifested as a sellar and suprasellar solid,solid-cystic or cystic mass.Surgical resection extent was related to the OS rate of the patients,while chemoradiotherapy had no statistical significance on OS.
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