Application of Enhanced CT Combined with Serum ESM-1 and UCHL1 in the Evaluation of the Efficacy of Targeted Therapy for Non-small Cell Lung Cancer
Objective To evaluate the effect of enhanced CT combined with serum endothelial cell specific molecule-1(ESM-1)and ubiquitin carboxyl terminal hydrolase L1(UCHL1)in evaluating the targeted therapy of non-small cell lung cancer(NSCLC).Methods A total of 112 patients with NSCLC admitted to our hospital from March 2020 to October 2022 were selected as the study subjects(NSCLC group),all of whom were treated with erlotinib hydrochloride tablets,and 112 patients who underwent physical examination in our hospital during the same period were collected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to measure serum levels of ESM-1 and UCHL1;the serum ESM-1,UCHL1 levels,and enhanced CT parameters were compared before and after treatment,and among patients with different treatment effects;the efficacy of enhanced CT combined with serum ESM-1 and UCHL1 in targeted therapy of NSCLC was evaluated.Results After targeted therapy,61 cases were effective,the total effective rate was 54.46％,51 cases were ineffective,and the ineffective rate was 45.54％;the serum levels of ESM-1 and UCHL1 in the NSCLC group were obviously higher than those in the control group(P＜0.05);after treatment,the levels of serum ESM-1 and UCHL1,and perfusion values in NSCLC patients were obviously reduced(P＜0.05),while there was no statistically obvious difference in pH,M/A,and Tp(P＞0.05);before and after treatment,the serum levels of ESM-1 and UCHL1 in the total effective group were obviously lower than those in the ineffective group(P＜0.05),before treatment,there was no statistically obvious difference in perfusion value and pH between the total effective group and the ineffective group(P＞0.05),and after treatment,the perfusion value and pH of the total effective group decreased(P＜0.05),while the perfusion value and pH of the ineffective group increased(P＜0.05);the consistency results showed that there was a high consistency between the perfusion value and PH determination results and the evaluation of solid tumor efficacy(Kappa=0.677,0.624,P＜0.001);the sensitivity,specificity,and accuracy of perfusion value combined with serum ESM-1,UCHL1,and PH combined with serum ESM-1 and UCHL1 to evaluate the efficacy of targeted therapy were 91.80％,86.89％,92.16％,86.27％,and 91.96％,86.61％,respectively,which were obviously higher than those of enhanced CT serum ESM-1,and UCHL1 alone(P＜0.05).Conclusion Enhanced CT combined with serum ESM-1 and UCHL1 is helpful to evaluate the efficacy of targeted therapy,and can guide clinical formulation and adjustment of further diagnosis and treatment programs.
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