The Application Value of Multimodal MRI in the Diagnosis of Pulmonary Inflammatory Nodules and Lung Cancer
Objective To discuss the application value of multimodal MRI in the diagnosis of pulmonary inflammatory nodules and lung cancer.Methods Twenty five patients with pulmonary inflammatory nodules and 25 patients with lung cancer confirmed by pathology or clinical follow-up were collected.All patients underwent CT plain scanning and multimodal MRI scanning.MRI sequences included axial T1WI,axial T2WI,axial T2WI lipid compression,and multi-b-value DWI scanning.The b value of multi-b-value DWI sequence was set as 600,800,1000,1200,1500,and 2000s/mm2.ADC values of the lesions under different b values were measured.Chi-square test was used to compare the CT and MRI signs of lung cancer.T test or Mann-Whitney U test of two independent samples were used to compare ADC values of two groups with different b values.MedCalc 11.4 software was used to draw the ROC curve and calculate the area under the curve.Delong test was used to compare the diagnostic efficiency of ROC curves of ADC values with different b values.Results There were statistical differences in bronchial stenosis or truncation between pulmonary inflammatory nodules group and lung cancer group(P＜0.05),but no statistical differences in other signs(P＞0.05).In the pulmonary inflammatory nodules group,isosignal and low signal were dominant on T1WI,and high signal was dominant on T2Wl.In lung cancer group,isosignal and mixed signal were dominant on T1WI,high signal and mixed signal were dominant on T2WI.ADC values of pulmonary inflammatory nodules group and lung cancer group were statistically different with different b values(P＜0.05),and ADC values of lung cancer group were lower than those of pulmonary inflammatory nodules group with different b values.With the increase of b value,ADC value in lung cancer group decreased significantly.By drawing the ROC curves of ADC values with different b values,it is found that b value 1000 had the highest diagnostic efficiency,with an AUC of 0.934(0.826-0.985),sensitivity of 96％,specificity of 92％,and the diagnostic threshold value was 1.25×10-3mm2/s.Conclusion Multimodal MRI has an important value in the differential diagnosis of pulmonary inflammatory nodules and lung cancer,and can provide more information for clinical diagnosis and treatment plan.
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