Clinical Value of CT Pulmonary Angiography Combined with Serum Apelin-13 and IL-38 in the Diagnosis of Acute Pulmonary Embolism
Objective To explore the clinical value of CT pulmonary angiography(CTPA)combined with serum Apelin-13 and interleukin-38(IL-38)in the diagnosis of acute pulmonary embolism(APE).Methods From May 2021 to May 2023,116 suspected APE patients admitted to our hospital were selected,all of whom underwent CTPA.According to their test results,they were grouped into APE group and non APE group;enzyme linked immunosorbent assay(ELISA)was applied to detect the levels of Apelin-13 and IL-38;the influencing factors of APE were analyzed using multiple Logistic regression analysis;ROC curve was plotted to analyze the diagnostic value of serum Apelin-13 and IL-38 for APE.Results Among 116 patients,49 cases(42.24％)were diagnosed with APE through CTPA,mainly including 23 cases of central heart type,82 cases of eccentric heart type,15 cases of wall thrombus type,and 19 cases of complete occlusion type.The serum levels of Apelin-13 and IL-38 in the APE group were obviously higher than those in the non APE group(P＜0.05).Multivariate Logistic regression analysis revealed that Apelin-13 and IL-38 were risk factors affecting APE(P＜0.05).According to the ROC curve,the AUC for diagnosing APE with serum Apelin-13 was 0.859,and the AUC for diagnosing APE with serum IL-38 was 0.864,the AUC for diagnosing APE with the combination of the two was 0.952,and the combination of the two was better than their respective individual diagnoses(Zcombination vs Apelin-13=2.681,Zcombinationvs IL-38=2.739,P＜0.05).Conclusion Apelin-13 and IL-38 are obviously elevated in the serum of APE patients,and CTPA can display the location and type of APE.The combination of CTPA and serum Apelin-13 and IL-38 can improve the diagnostic value for APE.
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