Value of Multi-spiral CT Combined with HMGB1 in Diagnosis of Congenital Thoracic Malformations in Children
Objective To explore the diagnostic value of multi-spiral CT combined with HMGB1 in children with congenital thoracic malformations.Methods Fifty-seven children with suspected thoracic malformation treated in our hospital from March 2021 to March 2023 were selected as the study objects.With surgical diagnosis as the"gold standard",43 children with confirmed thoracic malformation were selected as the observation group,and the other 14 children with non-thoracic malformation were selected as the control group.Serum HMGB1 levels were detected in observation group and control group.The children in observation group were examined by MSCT scan,and the relevant CT data were recorded.The basic data of the control group and the observation group were compared.CT data and serum HMGB1 levels of different subtypes and acute severity were compared in the observation group.To compare the detection rate and diagnostic value of MSCT scanning,serum HMGB1 level detection and their combination in congenital infundibular chest.Results There were no significant differences in gender,age and BMI between control group and observation group(P＞0.05).Serum HMGB1 level in observation group was significantly higher than that in control group(P＜0.05).There were no significant differences in Hailer index,cardiac rotation Angle,sternal depression depth,CT depression index,sternal depression Angle and serum HMGB1 level among children with different subtypes of infundibular chest(P＞0.05).The Hailer index,heart rotation Angle,depth of sternal depression,CT depression index and serum HMGB1 level in children with mild infundibular chest were lower than those in children with moderate and severe infundibular chest,and the Angle of sternal depression was higher than those in children with moderate and severe infundibular chest(P＜0.05).The Hailer index,cardiac rotation Angle,sternal depression depth,CT depression index and serum HMGB1 level in children with moderate infundibular chest were lower than those with severe infundibular chest,and the sternal depression Angle was higher than those with severe infundibular chest(P＜0.05).The detection rate of funnel chest by MSCT combined with HMGB1 was 90.70％,which was much higher than 69.77％by MSCT scan and 41.86％by serum HMGB1 level detection(P＜0.05).ROC curve analysis of the sensitivity and specificity of MSCT scan,serum HMGB1,and combined detection for congenital infundibulus chest showed that the sensitivity,specificity and AUC of the combined detection were higher than that of MSCT scan and serum HMGB1.Condusion MSCT combined with HMGB1 can effectively diagnose congenital thoracic malformation in children,and has high diagnostic value.
Multi-spiral CTHigh Mobility Protein B1Congenital Thoracic MalformationFunnel ChestDiagnostic Value
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