Study on Identification of HER2 Positive Breast Cancer Using Dynamic Contrast Enhanced Magnetic Resonance Imaging
Objective To evaluate the role of quantitative and semi quantitative parameters based on dynamic contrast enhanced magnetic resonance imaging(DCE-MRI)in discriminating three negative breast cancer and HER2 positive breast cancer.Methods A retrospective study was conducted to collect 147 female breast cancer patients(mean age 52.91±28.09 years).All patients underwent 3.OT MRI examination.The parameters of DCE-MRI included:volume transport constant(Ktrans),rate constant(kep),extravascular extracellular volume fraction(ve),plasma volume fraction(vp),time to peak(TTP),maximum concentration(Max conc),initial area under enhancement curve(AUC),time to peak(TTP)The maximum slope has four semi quantitative parameters.According to the results of immunohistochemistry,the patients were divided into 2 groups(HER2 positive group vs non HER2 positive group).Univariate analysis was used to analyze the differences between groups;Two variables Logistic regression was used to deal with data with statistical difference between groups,and to study the value of parameters in molecular typing of breast cancer.Results Ktrans,kep,ve,vp,TTP,MAX Conc,AUC,and MAX Slope were statistically different between the HER2-positive breast cancer group and the non-HER2-positive breast cancer group.kep,TTP and the combined model were diagnostic for HER2-positive breast cancer(AUC=0.763,0.733,0.832,all P＜0.020,by DeLong test).Conclusion DCE-MRI quantitative parameters and semi-quantitative parameters are independent diagnostic factors of HER2-positive breast cancer.The kep,TTP and combination diagnostic models have diagnostic value for HER2-positive breast cancer,and the combined models have higher diagnostic efficiency.
Dynamic Contrast-enhanced MRIRate Constant(kep)Molecular Typing of Breast CancerHER2 Positive Breast Cancer
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