MRI Characteristics and Their Relationship with PR,ER and CerbB-2 in Patients with Breast Cancer
Objective To explore magnetic resonance imaging(MRI)characteristics and their relationship with progesterone receptor(PR),estrogen receptor(ER)and proto-oncogene(CerbB-2)in patients with breast cancer.Methods The clinical data were collected from 86 patients with breast cancer treated in the hospital between May 2021 and May 2023.All patients underwent MRI examination before surgery.Immunohistochemical staining of pathological specimens was conducted after surgery.The positive rates of PR,ER and CerbB-2 in cancer tissues were calculated.The positive expressions of PR,ER and CerbB-2 in patients with different clinical characteristics and MRI characteristics were compared.The relationship between positive expressions of PR,ER and CerbB-2 in cancer tissues and MRI characteristics was analyzed by Spearman correlation analysis.Results In the 86 patients with breast cancer,there were 63 cases(73.26％),51 cases(59.30％)and 56 cases(65.12％)with positive PR,ER and CerbB-2,respectively.There were significant differences in positive expression rates of PR,ER and CerbB-2 among patients with different tumor differentiation,tumor size and TNM staging(P＜0.05),but there was no significant difference among patients with different age and lymph node metastasis(P＞0.05).There were significant differences in positive expression rates of PR,ER and CerbB-2 among patients with different tumor margins,enhancement modes and dynamic enhancement modes(P＜0.05),but there was no significant difference among patients with different tumor morphology(P＞0.05).Spearman correlation analysis showed that positive expressions of PR,ER and CerbB-2 in cancer tissues were positively correlated with enhancement modes and dynamic enhancement modes(P＜0.05).Condusion The positive expressions of PR,ER and CerbB-2 in cancer tissues are related to the progression of breast cancer.Clinically,MRI characteristics can be applied to evaluate tumor progression and guide clinical treatment.
Breast CancerMagnetic Resonance imagingProgesterone ReceptorEstrogen ReceptorProtooncogene
NETL
NSTL
万方数据
