Analysis of the Relationship between Serum PSA and Postoperative Bone Metastases Based on Two-parameter MRI Texture Analysis of Prostate Cancer Primary Lesions
Objective To investigate the relationship between serum prostate specific antigen(PSA)and postoperative bone metastases based on the texture analysis of two-parameter magnetic resonance imaging(bpMRI)based on the primary lesions of prostate cancer.Methods 134 patients with prostate cancer admitted to our hospital from January 2019 to January 2022 were selected.The patients were admitted to hospital for bpMRI and serum PSA examination,and underwent laparoscopic radical prostatectomy.The patients were followed up for 1 year.According to the postoperative bone metastasis,the patients were divided into metastatic group(n=62)and non-metastatic group(n=66).Logistic regression model was used to analyze the risk factors.The predictive value was evaluated using receiver operating characteristic curve(ROC).Results There was no significant difference in apparent diffusion coefficient(ADC)kurtosis,ADC skewness,T2WI kurtosis,T2WI skewness between 2 groups(P＞0.05).ADC entropy and T2WI entropy in metastatic group were higher than those in non-metastatic group(P＜0.05).There was no significant difference in age,clinical stage,hypertension,diabetes and tumor diameter between 2 groups(P＞0.05).The Gleason pathological score,alkaline phosphatase(ALP)and serum PSA levels in the metastatic group were higher than those in the non-metastatic group,while the hemoglobin(Hb)level in the metastatic group was lower than that in the non-metastatic group(P＜0.05).Multivariate Logistic regression analysis showed that high ADC entropy,T2WI entropy,Gleason pathological score,ALP and serum PSA were all risk factors for postoperative bone metastasis(P＜0.05).ROC curve analysis showed that the AUCs of serum PSA,ADC entropy,T2WI entropy and their combination in predicting the risk of bone metastasis after radical prostate cancer surgery were 0.858,0.734,0.576 and 0.925,respectively,and the combined predictive efficacy of the three indexes was higher than that of single test(P＜0.05).Conclusion High levels of ADC entropy,T2-WI entropy and serum PSA are risk factors for postoperative bone metastasis in prostate cancer patients,and the combination of these three factors has a high predictive value for postoperative bone metastasis.
Prostate CancerTwo-parameter Magnetic Resonance Imaging Texture AnalysisSerum PSABone Metastasis
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