腰椎脂肪分数联合R2*值对骨质疏松症的诊断价值分析
Analysis of Diagnostic Value of Lumbar Spine Fat Fraction Combined with R2*Value for Osteoporosis
刘鹏飞 1连振刚 2李逵蒙1
作者信息
- 1. 张家口市第一医院骨三科(河北张家口 075000)
- 2. 张家口市第一医院骨一科(河北张家口 075000)
- 折叠
摘要
目的 探讨腰椎脂肪分数(FF)和R2*值在骨质疏松症的诊断价值.方法 回顾性分析2022年1月至2023年12月在我院收治的120例慢性腰痛患者的临床资料.全部患者完成腰椎磁共振成像(MRI)及双能X线(DXA)检查.分析FF、R2*和骨密度(BMD)的相关性.采用受试者工作特征(ROC)曲线评估FF和R2*在骨质疏松症的诊断价值.结果 按照T值的不同分为三组,包括骨质正常组30例、骨质降低组41例、骨质疏松症组49例.三组患者的年龄、体重指数、BMD、FF、R2*无明显差异(P＜0.05).R2*和BMD呈正相关(r=0.5339,P＜0.05);FF和BMD呈负相关(r=-0.6470,P＜0.05);FF对骨质疏松症的诊断效能AUC为0.893(95％CI:0.837～0.949),截断值为56.09％,敏感度、特异度分别为83.70％、83.10％,约登指数为0.668.R2*对骨质疏松症的诊断效能AUC为0.843(95％CI:0.771～0.914),截断值为138.31Hz,敏感度、特异度分别为79.60％、81.70％,约登指数为0.613.二者联合诊断骨质疏松症的AUC为0.931(95％CI:0.889～0.973),敏感度、特异度分别为77.60％、93.00％,约登指数为0.705.二者联合诊断效能优于二者单独使用的诊断效能(P＜0.05).结论 腰椎R2*和FF均与骨密度密切相关,定量评估骨质疏松症,二者联合可显著提高诊断骨质疏松症的价值.
Abstract
Objective To explore the diagnostic value of lumbar fat fraction(FF)and R2*value in osteoporosis.Methods A retrospective analysis was conducted on the clinical data of 120 patients with chronic low back pain admitted to our hospital from January 2022 to December 2023.All patients completed lumbar magnetic resonance imaging(MRI)and dual energy X-ray(DXA)examinations.Analyze the correlation between FF,R2*,and bone density(BMD).Evaluate the diagnostic value of FF and R2*in osteoporosis using receiver operating characteristic(ROC)curves.Results Divided into three groups according to different T values,including 30 cases in the normal bone group,41 cases in the osteopenia group,and 49 cases in the osteoporosis group.There was no significant difference in age,body mass index,BMD,FF,and R2*among the three groups of patients(P＜0.05).R2*is positively correlated with BMD(r=0.5339,P＜0.05);FF and BMD are negatively correlated(r=-0.6470,P＜0.05).The diagnostic efficacy of FF for osteoporosis(AUC)was 0.893(95％Cl:0.837-0.949),with a cutoff value of 56.09％.The sensitivity and specificity were 83.70％and 83.10％,respectively,and the Jordan index was 0.668.The diagnostic efficacy AUC of R2*for osteoporosis is 0.843(95％Cl:0.771～0.914),with a cutoff value of 138.31Hz,sensitivity and specificity of 79.60％and 81.70％,respectively,and a Jordan index of 0.613.The AUC for the combined diagnosis of osteoporosis was 0.931(95％Cl:0.889～0.973),with sensitivity and specificity of 77.60％and 93.00％,respectively,and a Jordan index of 0.705.The combined diagnostic efficacy of the two is better than that of using them alone(P＜0.05).Condusion Lumbar R2*and FF are closely related to bone density,and quantitative evaluation of osteoporosis can significantly improve the diagnostic value of osteoporosis when combined.
关键词
磁共振成像/腰椎/R2*/脂肪分数/骨质疏松症/诊断价值/骨密度Key words
Magnetic Resonance imaging/Lumbar Vertebra/R2*/Fat Fraction/Osteoporosis/Diagnostic Value/Bone Mineral Density引用本文复制引用
基金项目
张家口市重点研发计划项目(2121059D)
出版年
2024
NETL
NSTL
万方数据