Study on Insomnia Network Based on Focal Lesions of Stroke
Objective This study investigates the relationship between focal brain lesions in stroke patients and post-stroke insomnia.By exploring the neuroanatomical basis of post-stroke insomnia,we aim to provide novel insights for its diagnosis and treatment.Methods This study prospectively enrolled 50 stroke patients.Insomnia severity was quantitatively assessed using Insomnia Severity Index Scale,categorizing patients into insomnia and non-insomnia groups.Employing voxel lesion symptom mapping,we examined the association between insomnia and lesion location.We calculated lesion network maps using a large standard connectome dataset(N=1000)to test for associations with insomnia.The results were then used to locate insomnia networks.Furthermore,we demonstrated the reliability of the insomnia network by analyzing the link between the network impairment score test and insomnia.Results Voxel lesion symptom mapping did not reveal significant associations between specific lesion voxels and insomnia.However,in lesion network mapping analysis,we found that lesion locations mapped to a brain network centered around the right thalamus.This network exhibited significantly greater overlap with focal lesions in insomnia patients compared to the non-insomnia group.Conclusion Lesion locations associated with insomnia fail to map to a specific brain region but do map to a specific brain network.This network may have prognostic utility in identifying patients at risk for poststroke insomnia and therapeutic utility in refining brain stimulation targets.
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