Cerebral Blood Flow Changes in Breast Cancer Patients without Significant Postoperative Cognitive Dysfunction
Objective To explore the changes of cerebral blood flow(CBF)in breast cancer patients after surgery by using pseudo continuous artery spin labeling(PCASL)technique,and to study the changes of cognitive function in breast cancer patients after surgery by using Neuropsychology scale.Methods Twenty-seven patients with invasive ductal carcinoma of the breast who underwent surgery and 33 healthy volunteers matched for age and education were selected.All subjects were assessed with the Neuropsychology scale and the whole brain CBF and T1 high-resolution structural image data were collected.General data,Neuropsychology scale scores and correlation analysis were analyzed by SPSS 19.0 software,and magnetic resonance data were analyzed by SPM-8 software.Results Compared with the healthy control group,the patients with breast cancer after surgery had no significant difference in age,education years and Neuropsychology scale scores,but the CBF in the left parahippocampal gyrus,left insular lobe,bilateral superior frontal gyrus and right posterior-medial frontal cortex decreased,and the course of disease after surgery was positively correlated with the CBF in the right posterior-medial frontal cortex and bilateral superior frontal gyrus.Conclusion Although the cognitive function of breast cancer patients does not decrease after surgery,anesthesia surgery still leads to multiple brain blood flow reduction.The abnormal cerebral blood flow perfusion in the right posterior-medial frontal cortex and bilateral superior frontal gyrus improved with time,suggesting that the pathological process is reversible.
Breast CancerSurgeryAnesthesiaPostoperative Cognitive Dysfunction
NETL
NSTL
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