The Value of Whole Tumors Volume Based Enhancement MRI Histogram Analysis Of Differential Diagnosis in Children with Astrocytoma and Ependymoma
Objective To explore the practical value of T1 global gray histogram analysis in the differential diagnosis of posterior fossa astrocytoma and ependymoma in children.Methods In this study,51 cases of posterior cranial fossa tumor diagnosed by MRI and pathology in our hospital database were analyzed retrospectively.Of these 51 cases,26 were astrocytomas(12 males and 14 females)and 25 were ependymomas(13 males and 12 females).Patients ranged in age from 1 to 12 years,with an average age of(5.5±2.3)years.We used Mazda software to precisely delineate regions of interest at each tumor level in two sets of MR Enhanced T1 sagittal images,and performed comprehensive gray scale global histogram analysis.Then,we conducted a detailed statistical comparison of these two groups of histogram parameters,aiming to deeply analyze the statistical significance of each parameter in the differential diagnosis,in order to provide a more effective auxiliary means for the accurate diagnosis of posterior cranial fossa tumors in children.Results In the in-depth analysis of the nine parameters extracted by enhancing the T1 global gray histogram,We found that four of these parameters-Variance,Skewness,first percentile(Perc.01％),and 10th percentile(Perc.10％)-were statistically significant(P＜0.05),which provides strong data support for our study.In particular,Variance has a sensitivity of 73.3％,a specificity of 61.9％,and an area under the curve(AUC)of 0.731,showing excellent discrimination efficiency.Further,we determined that the optimal threshold of Variance is 740.71,which provides a clear reference standard for our diagnosis.Conclusion Enhanced T1 global gray histogram analysis is of great value in the differential diagnosis of posterior fossa astrocytoma and ependymoma in children.This method can not only provide doctors with a new diagnostic perspective,but also is expected to become an effective auxiliary diagnostic tool for these two types of children's posterior cranial fossa tumors,and bring positive impact on our medical practice.
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