Clinical Study of Expanding Coronary Tree Reconstruction to Smaller Arteries to Improve the Accuracy of FFRCT
Objective This study aims to improve the accuracy of coronary CT angiography(CCTA)based blood flow reserve fraction(FFR)by expanding the coronary tree in the field of computational fluid dynamics(CFD).A Observational study was conducted to evaluate the effect of expanding the coronary tree analysis from a minimum diameter of 1.2 mm to 0.8 mm.Methods A retrospective study was conducted on patients receiving CCTA and interventional FFR treatment.76 patients met the inclusion criteria.Reconstruct a three-dimensional coronary artery tree and generate a finite element mesh with different lower limits of lumen diameter(1.2 mm and 0.8 mm).The exit boundary conditions are defined according to Murray's law.Apply the NKS method to solve the CFD control equation and obtain FFRCT.Results At the individual patient level,expanding the minimum diameter of the coronary artery tree from 1.2mm to 0.8mm increased the sensitivity of FFRCT by 16.7％(P=0.022),resulting in four false negative cases turning into true positive cases.AUC value of Receiver operating characteristic increased from 0.74 to 0.83.In addition,the NKS method can solve the computational problem of expanding the coronary artery tree to 0.8 mm lumen diameter within 10.5 minutes with 2160 processor cores.Conclusion Expanding the reconstructed coronary artery to a smaller lumen diameter can significantly improve the sensitivity of FFRCT,and the NKS method can provide good computational time for future clinical applications.
NETL
NSTL
万方数据
