Analysis of Relationship between MRI Characteristics and Pathological Grading and Molecular Typing in Patients with Breast Cancer
Objective To investigate the relationship between MRI characteristics and pathological grading and molecular typing in patients with breast cancer.Methods The medical records of 60 patients with breast cancer confirmed by histopathology in the hospital were collected from January 2020 to December 2023.All patients completed MRI examination before receiving any treatment,and the correlation of MRI characteristics with pathological grading and molecular typing was analyzed.Results Among the 60 patients,there were 3 cases(5.00％)of pathological grade Ⅰ,33 cases(55.00％)of grade Ⅱ and 24 cases(40.00％)of grade Ⅲ.The tumor diameter of grade Ⅰ patients was smaller than that of grade Ⅱand grade Ⅲ(P＜0.05),but there was no statistical difference between grade Ⅱ and grade Ⅲ(P＞0.05).The enhancement curve of grade Ⅰ patients was dominated by inflow type,accounting for 66.67％,while that of grade Ⅱ or grade Ⅲ patients was dominated by platform type,accounting for 75.76％or 70.83％(P＜0.05).The 60 patients were classified into molecular type Luminal A(12 cases,20.00％),Luminal B(37 cases,61.67％),Her2 overexpression type(4 cases,6.67％)and Triple-Negative type(7 cases,11.67％).Luminal A and Luminal B patients had unclear edges,while Her2 overexpression and Triple-Negative patients had 1 patient with clear edge(P＜0.05).The tumor diameter of Triple-Negative type was the largest,and that of Luminal B type was the smallest(P＜0.05).The MRI apparent diffusion coefficient of Her2 overexpression type was the largest,and that of Luminal A type was the smallest(P＜0.05).The early enhancement rate of Triple-Negative type was the highest,and that of Her2 overexpression type was the lowest(P＜0.05).Conclusion MRI characteristics of breast cancer patients are related to pathological grading and molecular typing.It is necessary to pay attention to tumor size,lesion edge and internal enhancement.
Breast CancerMagnetic Resonance imagingPathological GradingMolecular Typing
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