Evaluation Value of MRI Multi-sequence Scanning Combined with Serum SCCA,CA153 and VEGF in Diagnosis and Prognosis of Cervical Cancer
Objective To analyze the value of magnetic resonance imaging(MRI)multi-sequence scan combined with serum squamous-cell cancer cancer(SCCA),glycan 153(CA153),and vasodilular growth factor(VEGF)in the diagnosis and prognosis of cervical cancer.Methods A total of 269 patients with cervical cancer(malignant group)admitted to our hospital from June 2016 to June 2020 were selected as the research objects,and 120 patients with benign cervical lesions confirmed by pathological diagnosis during the same period were selected as the benign group.At the same time,the patients with cervical cancer were divided into relapse group(n=40)and non-relapse group(n=229)based on the relapse within 3 years after discharge.All the patients underwent dynamic contrast-enhanced MRI(DCE-MRI)and diffuse weighted-MRI(DWI-MRI)to obtain quantitative parameters.The levels of SCCA,CA153,and VEGF in the blood were determined.The receiver operating characteristic curve(ROC)was used to analyze the value of MRI multi-sequence scanning parameters combined with serum SCTA,CA153,and VEGF in the diagnosis and prognosis of cervical cancer.Results The ADC value of the malignant group was lower than that of the benign group,but the volume transport constant(Ktrans),the rate constant(Kep),the ratio of the extravasated space(Ve),and the levels of SCTA,CA153,and VEGF in the serum of the malignant group were higher than those of the benign group(P＜0.05).The ADC value of the relapse group was lower than that of the non-relapse group,and the levels of Ktrans,Kep,Ve,and serum SCCA,CA153,and VEGF were higher than those of the non-relapse group(P＜0.05).The results of the ROC curve analysis showed that the area under the curve(AUC)of MRI multi-sequence scanning parameters combined with serum SCCA,CA153,and VEGF in evaluating cervical cancer was 0.971,the sensitivity was 94.1％,and the specialty was 93.2％.MRI multi-sequence scan parameters combined with serum SCCA,CA153,and VEGF for evaluating the prognosis of cervical cancer patients had an AUC of 0.938,a sensitivity of 93.0％,and a specialty of 80.6％.The combined evaluation was superior to the individual evaluation of each index.Conclusion The results showed that the parameters of MRI multi-sequence scanning,serum SCCA,CA153,and VEGF were of certain value in the diagnosis and prognosis of cervical cancer.Moreover,the parameters of MRI multi-sequence scanning combined with serological indicators could significantly improve the diagnosis efficiency.
NETL
NSTL
万方数据
