T2DM患者胸椎椎体松质骨CT值变化及临床意义探究
Relationship among CT Value of the Cancellous Bone of the Thoracic Vertebrae,Bone Metabolism Indicators and Coronary Artery Lesions in Patients with T2DM
罗伊丽 1曹涵 1刘璐2
作者信息
- 1. 上海交通大学医学院附属松江医院内分泌科(上海 201600)
- 2. 上海中医药大学附属第七人民医院内分泌科(上海 200120)
- 折叠
摘要
目的 探究2型糖尿病(T2DM)患者胸椎椎体松质骨CT值变化及临床意义.方法 选取医院2021年1月～2023年12月收治的89例T2DM患者(为T2DM组)和同期体检健康志愿者35例(为常规组)为研究对象,两组均行螺旋CT检查,比较T2DM组、常规组一般资料、CT值和骨代谢指标,分析T2DM患者胸椎椎体松质骨CT值与骨代谢指标的相关性,明确冠脉病变对T2DM患者胸椎椎体松质骨CT值、骨代谢指标影响,明确T2DM患者胸椎椎体松质骨CT值与冠脉病变的关系.结果 与常规组比较,T2DM组空腹血糖、糖化血红蛋白、骨特异性碱性磷酸酶(BAP)、甲状旁腺激素(PTH)、β-胶联降解产物(β-CTX)明显高,胸椎椎体松质骨CT值、BGP明显低(P＜0.05).Pearson相关分析提示T2DM患者胸椎椎体松质骨CT值与BGP呈正比,与BAP、PTH、β-CTX呈负相关(P＜0.05).与无冠脉病变患者比较,冠脉病变患者BAP、PTH、β-CTX明显高,胸椎椎体松质骨CT值、BGP明显低(P＜0.05).随冠脉病变累及分支数增加患者胸椎椎体松质骨CT值随之明显降低,组间两两比较差异有统计学意义(P＜0.05).结论 T2DM患者胸椎椎体松质骨CT值与骨代谢指标及冠脉病变均密切相关,有必要为T2DM患者定期进行螺旋CT检查,通过胸椎椎体松质骨CT值初步评估患者骨质疏松症及冠脉病变的风险.
Abstract
Objective To investigate the relationship among CT value of the cancellous bone of the thoracic vertebrae,bone metabolism indicators and coronary artery disease in patients with type 2 diabetes mellitus.Methods A total of 89 patients with T2DM(T2DM group)admitted to the hospital from January 2021 to December 2023 and 35 healthy volunteers(routine group)who received physical examinations in the same hospital during the same period were selected as the study subjects.Both groups received spiral CT examination.Their general information,CT values,and bone metabolism indicators were comparatively analyzed.The correlation between CT value of the cancellous bone of the thoracic vertebrae and bone metabolism indicators in patients with T2DM was analyzed.The influence of coronary artery lesions on CT value of the cancellous bone of the thoracic vertebrae and bone metabolism indicators in patients with T2DM was discussed.The relationship between CT value of the cancellous bone of the thoracic vertebrae and coronary artery lesions in patients with T2DM was identified.Results Compared with the routine group,T2DM group had significantly higher levels of fasting blood glucose,glycated hemoglobin,bone-specific alkaline phosphatase(BAP),parathyroid hormone(PTH)and β-collagen degradation product(β-CTX),and significantly lower CT value of the cancellous bone of the thoracic vertebrae and BGP level(P＜0.05).Pearson correlation analysis found that the CT value of the cancellous bone of the thoracic vertebrae was positively correlated with BGP,and negatively correlated with BAP,PTH and β-CTX in patients with T2DM(P＜0.05).Compared with patients without coronary artery lesions,patients with coronary artery lesions had significantly higher levels of BAP,PTH and β-CTX,and significantly lower CT value of the cancellous bone of the thoracic vertebrae and BGP level(P＜0.05).As branches involved by coronary artery lesions increased,CT value of the cancellous bone of the thoracic vertebrae in patients with coronary artery lesions decreased significantly,with statistically significant differences between any two groups(P＜0.05).Conclusion CT value of the cancellous bone of the thoracic vertebrae is closely related to bone metabolism indicators and coronary artery lesions in patients with T2DM.It is necessary to examine patients with T2DM regularly using spiral CT so as to preliminarily evaluate the risk of osteoporosis and coronary artery lesions through the CT value of the cancellous bone of the thoracic vertebrae.
关键词
2型糖尿病/胸椎椎体松质骨/CT值/骨代谢/冠脉病变Key words
Type 2 Diabetes Mellitus/Cancellous Bone of the Thoracic Vertebrae/CT Value/Bone Metabolism/Coronary Artery Lesion引用本文复制引用
基金项目
国家自然科学基金青年科学基金(81903690)
出版年
2024
NETL
NSTL
万方数据