Relationship among CT Value of the Cancellous Bone of the Thoracic Vertebrae,Bone Metabolism Indicators and Coronary Artery Lesions in Patients with T2DM
Objective To investigate the relationship among CT value of the cancellous bone of the thoracic vertebrae,bone metabolism indicators and coronary artery disease in patients with type 2 diabetes mellitus.Methods A total of 89 patients with T2DM(T2DM group)admitted to the hospital from January 2021 to December 2023 and 35 healthy volunteers(routine group)who received physical examinations in the same hospital during the same period were selected as the study subjects.Both groups received spiral CT examination.Their general information,CT values,and bone metabolism indicators were comparatively analyzed.The correlation between CT value of the cancellous bone of the thoracic vertebrae and bone metabolism indicators in patients with T2DM was analyzed.The influence of coronary artery lesions on CT value of the cancellous bone of the thoracic vertebrae and bone metabolism indicators in patients with T2DM was discussed.The relationship between CT value of the cancellous bone of the thoracic vertebrae and coronary artery lesions in patients with T2DM was identified.Results Compared with the routine group,T2DM group had significantly higher levels of fasting blood glucose,glycated hemoglobin,bone-specific alkaline phosphatase(BAP),parathyroid hormone(PTH)and β-collagen degradation product(β-CTX),and significantly lower CT value of the cancellous bone of the thoracic vertebrae and BGP level(P＜0.05).Pearson correlation analysis found that the CT value of the cancellous bone of the thoracic vertebrae was positively correlated with BGP,and negatively correlated with BAP,PTH and β-CTX in patients with T2DM(P＜0.05).Compared with patients without coronary artery lesions,patients with coronary artery lesions had significantly higher levels of BAP,PTH and β-CTX,and significantly lower CT value of the cancellous bone of the thoracic vertebrae and BGP level(P＜0.05).As branches involved by coronary artery lesions increased,CT value of the cancellous bone of the thoracic vertebrae in patients with coronary artery lesions decreased significantly,with statistically significant differences between any two groups(P＜0.05).Conclusion CT value of the cancellous bone of the thoracic vertebrae is closely related to bone metabolism indicators and coronary artery lesions in patients with T2DM.It is necessary to examine patients with T2DM regularly using spiral CT so as to preliminarily evaluate the risk of osteoporosis and coronary artery lesions through the CT value of the cancellous bone of the thoracic vertebrae.
Type 2 Diabetes MellitusCancellous Bone of the Thoracic VertebraeCT ValueBone MetabolismCoronary Artery Lesion
NETL
NSTL
万方数据
