Expression and Predictive Value of CT Quantitative Parameters in Delayed Healing of Limbs Fractures
Objective To investigate the expression and diagnostic value of CT quantitative parameters in delayed healing of limbs fractures.Methods A total of 300 patients with limb fracture admitted to Our hospital May 2020 to May 2023)were prospectively selected to statistically analyze the delayed healing of fractures 16 weeks after surgery,and grouped according to the delayed healing of fractures.The quantitative parameters of CT gap connexin 43(Cx43)and bone morphogenetic protein 2(BMP-2)of the two groups were compared.Pearson correlation coefficient was used to analyze the correlation between the two,and the predictive efficiency of receiver operating characteristic curve(ROC)and area under curve(AUC)analysis was plotted.Results(1)At 16 weeks after operation,8 cases of 300 patients with limb fracture were lost to follow-up,42 cases were delayed healing(14.38％).(2)The expression of BMD,BSICSA,BSICSMI and serum Cx43 and BMP-2 in delayed group were lower than those in normal group at 2,6 and 8 weeks after surgery(P＜0.05);(3)Pearson correlation coefficient showed that BMD,BSICSA and BSICSMI were significantly positively correlated with BMP-2 and Cx43 in patients with delayed limb fracture healing at 8 weeks after surgery(P＜0.05).At 2,6 and 8 weeks after surgery,BSICSA+BSICSMI+BMD predicted delayed healing of limb fractures(AUC:0.914,0.926,0.937),which was similar to BMP+Cx43(AUC:0.898,0.916,0.925),and the combined prediction of BSICSA+BSICSMI+BMD was the most effective at 8 weeks after surgery.Conclusion Quantitative CT parameters(BSICSA,BMD,BSICSMI)are low expression in patients with delayed union of limbs fractures,and the combined prediction of the three parameters is high,which is helpful for clinicians to develop personalized prevention and treatment measures to reduce the risk of delayed union of limbs fractures.
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