The Value of MRI Morphological Characteristics and Intratumoral and Peritumoral Apparent Diffusion Coefficient in Predicting IDH-1 Mutations in Different Grade Gliomas
Objective To investigate the value of MRI morphological characteristics and apparent diffusion coefficient(ADC value)in predicting IDH-1 mutations in low-grade gliomas(WHO2-3 grade)and WHO4-grade high gliomas.Methods The clinical,pathological and imaging data of 100 patients with pathologically confirmed glioma from January 2021 to May 2023 in the Affiliated Hospital of Xuzhou Medical University were retrospectively collected,including 44 cases of grade 2-3(32 cases of IDH-1 mutant type and 12 cases of wild type)and 56 cases of grade 4(10 cases of IDH-1 mutant type and 46 cases of wild type).Compare the measured ADC-related parameter values and the differences between IDH-1 mutant and wild type in different grades of glioma with conventional MRI morphological features.The receiver operating characteristic(ROC)curve was plotted to evaluate the predictive performance of various indicators.Results In lower-grade gliomas,IDH-1 mutant type was usually unfortified or mildly enhanced,and the difference with IDH-1 wild type was statistically significant.In the lower grade and WHOIV grade glioma,there were significant differences between the tADCmean,tADCmin and rADCt/C of IDH-1 wild type,tADCmin and tADCmean had the highest prediction efficiency for IDH-1 mutation,and the areas under the curve were 0.759 and 0.763,respectively.There were no significant differences in peritumor ADC parameters between the two groups.Conclusion MRI morphological characteristics and apparent diffusion coefficient have certain value in predicting IDH-1 gene mutation in glioma.
万方数据
维普
