目的 用18F-FDG PET/CT和静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)两种方法研究轻度认知障碍(mild cognitive impairment,MCI)及不同程度阿尔茨海默病(alzheimer'S disease,AD)的功能连接(functional connectivity,FC)、葡萄糖代谢的改变及差异.方法 对MCI、不同程度AD患者及10名健康人行PET/CT和静息态fMRI.计算全脑116个脑区的FC和标准摄取值比(standard uptake value ratio,SUVR),以双样本t检验比较5组内任意2组间FC和SUVR值的差异,以Pearson法对FC、SUVR、简易精神状态量表(mini-mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)相互进行相关性分析.结果 健康组与病例组、病例组之间均存在有差异的FC及SUVR值(P均＜0.05).FC与SUVR值存在显著相关性的脑区为左侧小脑9区(P＜0.05);FC与MMSE、MoCA均无显著相关性(P＞0.05).SUVR与MMSE、MoCA存在显著相关性的脑区包括双侧海马、双侧楔前叶等脑区(P＜0.05).结论 MCI、不同程度AD患者FC和SUVR值均存在差异,FC和葡萄糖代谢异常的脑区不仅在四大网络中,还出现在小脑中,18F-FDG与量表的相关性更好.
Resting-state fMRI Combined with 18F-FDG PET/CT in the Diagnosis of Alzheimer's Disease
Objective To study the changes and differences in FC and glucose metabolism in patients with MCI and AD by 18F-FDG PET/CT and resting-state fMRI.Methods 18F-FDG PET/CT and resting-state fMRI were performed in patients with MCI and different degrees of AD,and 10 healthy control.The FC and SUVR values in116 brain regions were calculated,and the differences in FC and SUVR values between the 2 groups within the 5 groups were compared by two-sample t-tests.FC,SUVR,MMSE and MoCA were correlated by Pearson's method.Results Differential FC and SUVR values were found between the healthy and case groups,and between the case groups.(P＜0.05);There was significant correlation between FC and SUVR value in left cerebellar region 9(P＜0.05).There was no significant correlation between FC and MMSE or MoCA(P＞0.05).The brain regions with significant correlation between SUVR and MMSE or MoCA were bilateral hippocampus,bilateral precuneus and other brain regions(P＜0.05).Conclusion There were differences in FC and SUVR values in patients with MCI and different degrees of AD,and the brain regions with abnormal FC and glucose metabolism appeared in in four major networks as well as in the cerebellum.The correlation between 18F-FDG and the scale was better.
PAIzheimer DiseaseResting-state Functional Magnetic Resonance ImagingPositron-emission TomographyFunctional Connection MatrixGlucose Metabolism
万方数据
维普
