Correlation Analysis of Magnetic Resonance Perfusion Imaging Parameters,T Staging,and Prognosis in Patients with Nasopharyngeal Carcinoma
Objective To analyze the correlation of perfusion weighted imaging(PWI)parameters,T staging,and prognosis in patients with nasopharyngeal carcinoma(NPC).Methods The clinical data of 58 patients with NPC admitted to the hospital from January 2019 to December 2020 were analyzed retrospectively.According to examination results,the patients were divided into a low stage group(26 cases)and a high stage group(32 cases).Baseline data,PWI parameters,and prognosis of the two groups were comparatively analyzed.Pearson method was used to analyze the correlation between PWI parameters and T stage.Multivariate logistic regression analysis was conducted to identify the risk factors for poor prognosis of NPC.The predictive performance of PWI parameters was evaluated using the receiver operating characteristic(ROC)curves.Results Among the 58 cases of NPC enrolled in this study,there were 11 cases in T1 stage,15 cases in T2 stage,23 cases in T3 stage,and 9 cases in T4 stage.The transfer coefficient(Ktrans)of extravascular extracellular space(EES)and rate constant(Kep)of contrast agent flowing from EES to plasma in the low stage group were higher than those in the high stage group(P＜0.05).There was no statistically significant difference in volume or plasma volume fraction between the two groups(P＞0.05).Pearson correlation analysis found that T stage was negatively correlated with Ktrans and Kep in patients with NPC(P＜0.05).The survival rate of the low stage group(88.46％)was significantly higher than that of the high stage group(43.75％)(P＜0.05).Logistic regression analysis results showed that decreased Ktrans and Kep were risk factors for poor prognosis of NPC(P＜0.05).ROC curve analysis showed that the AUC values of Ktrans and Kep for predicting poor prognosis of NPC were 0.745 and 0.892.The AUC of joint prediction with the two was 0.912,significantly higher than that of prediction with a single indicator(Z=3.585,8.786,P≤0.001,＜0.001).The sensitivity and specificity were 100.00％and 73.08％.Conclusion PWI parameters can be used to evaluate T stage and prognosis of NPC.Ktrans and Kep are negatively correlated with T stage,and can be used for prognosis evaluation.Joint detection of the two can improve predictive performance.
万方数据
维普
