Retrospective Study of DCE-MRI Quantitative Parameters Combine with Serum CEA and Cyfra21-1 in the Diagnosis of Mediastinal Lymph Node Metastasis in Non-small Cell Lung Cancer
Objective To investigate the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters combine with serum carcinoembryonic antigen(CEA)and cell albumin 19 fragment(Cyfra21-1)in the diagnosis of mediastinal lymph node metastasis(MLNM)in non-small cell lung cancer.Methods The clinical data of 147 non-small cell lung cancer patients who were admitted to Guigang People's Hospital from May 2020 to December 2022 were retrospectively analyzed,patients were divided into MLNM group(44 cases)and non-MLNM group(103 cases)according to the results of postoperative pathological diagnosis.Preoperative DCE-MRI quantitative parameters and serum CEA and Cyfra21-1 levels were detected in non-small cell lung cancer patients.The value of DCE-MRI quantitative parameters combined with serum CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer patients were analyzed by receiver operating characteristic(ROC)curve.Results The levels of Ktrans,Kep,Ve,serum CEA and Cyfra21-1 in MLNM group were higher than those in non-MLNM group(P＜0.05).The area under the curve of Ktrans,Kep,Ve,CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer was 0.758,0.618,0.609,0.643 and 0.730 respectively,the area under the curve of combined Ktrans,Kep,Ve,CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer was 0.872,which was higher than that of single diagnosis.Conclusion The DCE-MRI parameters Ktrans,Kep and Ve of non-small cell lung cancer MLNM patients increased,and the levels of serum CEA and Cyfra21-1 increased,the combination of DCE-MRI parameters and serum CEA and Cyfra21-1 detection can improve the diagnostic efficacy of MLNM.
Non-small Cell Lung CancerMediastinal Lymph Node MetastasisDynamic Contrast-enhanced Magnetic Resonance ImagingCarcinoembryonic AntigenCell Albumin 19 Fragment
万方数据
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