中国CT和MRI杂志2024，Vol.22Issue(9) ：50-52.DOI:10.3969/j.issn.1672-5131.2024.09.017

DCE-MRI定量参数联合血清CEA、Cyfra21-1诊断非小细胞肺癌纵隔淋巴结转移的回顾性研究

Retrospective Study of DCE-MRI Quantitative Parameters Combine with Serum CEA and Cyfra21-1 in the Diagnosis of Mediastinal Lymph Node Metastasis in Non-small Cell Lung Cancer

吴俊宏 李雪萍 孔少龙 杨健
中国CT和MRI杂志2024，Vol.22Issue(9) ：50-52.DOI:10.3969/j.issn.1672-5131.2024.09.017
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DCE-MRI定量参数联合血清CEA、Cyfra21-1诊断非小细胞肺癌纵隔淋巴结转移的回顾性研究

Retrospective Study of DCE-MRI Quantitative Parameters Combine with Serum CEA and Cyfra21-1 in the Diagnosis of Mediastinal Lymph Node Metastasis in Non-small Cell Lung Cancer

吴俊宏 1李雪萍 1孔少龙 1杨健1
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作者信息

  • 1. 贵港市人民医院影像科(广西贵港 537119)
  • 折叠

摘要

目的 探讨动态对比增强磁共振成像(DCE-MRI)定量参数联合血清癌胚抗原(CEA)、细胞白蛋白19片段(Cyfra21-1)诊断非小细胞肺癌纵隔淋巴结转移(MLNM)的价值.方法 回顾性分析2020年5月至2022年12月贵港市人民医院收治的147例非小细胞肺癌患者的临床资料,根据术后病理诊断结果分为MLNM组(44例)和非MLNM组(103例).检测非小细胞肺癌患者术前DCE-MRI定量参数和血清CEA、Cyfra21-1水平.采用受试者工作特征(ROC)曲线分析DCE-MRI定量参数联合血清CEA、Cyfra21-1诊断非小细胞肺癌患者发生MLNM的价值.结果 MLNM组Ktrans、Kep、Ve,血清CEA、Cyfra21-1 水平高于非MLNM组(P＜0.05).Ktrans、Kep、Ve、CEA、Cyfra21-1诊断非小细胞肺癌发生MLNM的曲线下面积分别为0.758、0.618、0.609、0.643、0.730,联合Ktrans、Kep、Ve、CEA、Cyfra21-1 诊断非小细胞肺癌发生MLNM的曲线下面积为0.872,高于单独诊断.结论 非小细胞肺癌MLNM患者的DCE-MRI参数Ktrans、Kep、Ve增加,血清CEA、Cyfra21-1水平升高,联合DCE-MRI参数和血清CEA、Cyfra21-1检测可提高对MLNM的诊断效能.

Abstract

Objective To investigate the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters combine with serum carcinoembryonic antigen(CEA)and cell albumin 19 fragment(Cyfra21-1)in the diagnosis of mediastinal lymph node metastasis(MLNM)in non-small cell lung cancer.Methods The clinical data of 147 non-small cell lung cancer patients who were admitted to Guigang People's Hospital from May 2020 to December 2022 were retrospectively analyzed,patients were divided into MLNM group(44 cases)and non-MLNM group(103 cases)according to the results of postoperative pathological diagnosis.Preoperative DCE-MRI quantitative parameters and serum CEA and Cyfra21-1 levels were detected in non-small cell lung cancer patients.The value of DCE-MRI quantitative parameters combined with serum CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer patients were analyzed by receiver operating characteristic(ROC)curve.Results The levels of Ktrans,Kep,Ve,serum CEA and Cyfra21-1 in MLNM group were higher than those in non-MLNM group(P＜0.05).The area under the curve of Ktrans,Kep,Ve,CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer was 0.758,0.618,0.609,0.643 and 0.730 respectively,the area under the curve of combined Ktrans,Kep,Ve,CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer was 0.872,which was higher than that of single diagnosis.Conclusion The DCE-MRI parameters Ktrans,Kep and Ve of non-small cell lung cancer MLNM patients increased,and the levels of serum CEA and Cyfra21-1 increased,the combination of DCE-MRI parameters and serum CEA and Cyfra21-1 detection can improve the diagnostic efficacy of MLNM.

关键词

非小细胞肺癌/纵隔淋巴结转移/动态对比增强磁共振成像/癌胚抗原/细胞白蛋白19片段

Key words

Non-small Cell Lung Cancer/Mediastinal Lymph Node Metastasis/Dynamic Contrast-enhanced Magnetic Resonance Imaging/Carcinoembryonic Antigen/Cell Albumin 19 Fragment

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基金项目

2020年度广西医药卫生自筹经费科研课题(20200811)

出版年

2024
中国CT和MRI杂志
北京大学深圳临床医学院 北京大学第一医院

中国CT和MRI杂志

CSTPCD
影响因子：1.578
ISSN：1672-5131
参考文献量13
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