Exploration on the Relationship between Pericoronal Fat Volume,FAI,PCATMA and Coronary Stenosis,Plaque Properties,Prognosis in Patients with Coronary Heart Disease Based on CTA
Exploration on the Relationship between Pericoronal Fat Volume,FAI,PCATMA and Coronary Stenosis,Plaque Properties,Prognosis in Patients with Coronary Heart Disease Based on CTA
Objective To explore the relationship between pericoronal fat volume,fat attenuation index(FAI),fat average attenuation(PCATMA)and coronary stenosis,plaque properties,prognosis in patients with coronary heart disease(CHD)based on computed tomography angiography(CTA).Methods A total of 121 patients with CHD treated in the hospital were enrolled between September 2020 and December 2022.All underwent CTA to measure pericoronal fat volume,FAI and PCATMA.According to severity of coronary stenosis,patients were divided into moderate group and severe group.According to plaque properties,patients were divided into non-calcification group,calcification group and mixed group.All patients were followed up for 1 year.According to presence or absence of major adverse cardiac events(MACE),patients were divided into MACE group and non-MACE group.The pericoronal fat parameters in different groups were compared.The influencing factors of MACE were analyzed by multivariate Logistic regression analysis,and their predictive value for MACE was evaluated by receiver operating characteristic(ROC)curves.Results The pericoronal fat volume and PCATMA in severe group were lower than those in moderate group,while FAI was higher than that in moderate group(P＜0.05).There were significant differences in pericoronal fat parameters among patients with different plaque properties(P＜0.05).The pericoronal fat volume in calcification group was higher than that in mixed group,PCATMA was higher than that in non-calcification group and mixed group,and FAI was lower than that in non-calcification group and mixed group(P＜0.05).The proportions of double-vessel or multi-vessel lesions and severe coronary stenosis,and FAI in MACE group were higher than those in non-MACE group,while PCATMA was lower than that in non-MACE group(P＜0.05).Multivariate Logistic analysis showed that severe coronary stenosis and high FAI were independent risk factors of MACE with 1-year follow-up(P＜0.05).AUC values of FAI,PCATMA and combined detection for predicting MACE were 0.736(0.634-0.838),0.673(0.572-0.774)and 0.857(0.785-0.930),respectively.AUC of combined detection was greater than that of single index(P＜0.05).Conclusion There are different CTA characteristics of pericoronal fat in CHD patients with different coronary stenosis degree and plaque properties.Severe coronary stenosis and high FAI are independent risk factors of MACE with 1-year follow-up.The combined detection of FAI and PCATMA has high predictive value for MACE.
维普
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