Evaluation Value of Enhanced CT Combined with SCC and Ca724 in Predicting Recurrence and Metastasis of Esophageal Squamous Cell Carcinoma after Radiotherapy and Chemotherapy
Objective To explore the value of enhanced CT combined with squamous cell carcinoma antigen(SCC)and carbohydrate antigen 724(Ca724)in predicting the recurrence and metastasis of esophageal squamous cell carcinoma after radiotherapy.Methods A total of 103 patients with esophageal squamous cell carcinoma who underwent radiotherapy and chemotherapy in our hospital from September 2021 to August 2023 were collected.Based on whether there was recurrence or metastasis after 6 months of treatment,they were divided into a good prognosis group(73 cases)and a poor prognosis group(30 cases).The general data,CT enhanced texture feature values,serum levels of SCC and Ca724 in the two groups were compared,the risk factors of recurrence and metastasis of esophageal squamous cell carcinoma patients after radiotherapy and chemotherapy were analyzed by logistic regression analysis,the predictive value was analyzed by receiver operating characteristic(ROC)curve.Results There were significant differences in clinical stage,tumor diameter and lymph node metastasis between the two groups(P＜0.05);the average CT value,CT enhancement degree,serum levels of SCC and Ca724 in the good prognosis group were lower than those in the poor prognosis group(P＜0.05);clinical stage,tumor diameter,lymph node metastasis,SCC,Ca724,average CT value and CT enhancement degree were risk factors for recurrence and metastasis after radiotherapy and chemotherapy(P＜0.05);the AUC of individual and combined prediction of each index was＞0.6,but the AUC of combined prediction was the highest,which was 0.864(P＜0.05).Conclusion Enhanced CT combined with SCC and Ca724 can provide an effective reference for clinical prediction of recurrence and metastasis of esophageal cancer patients after radiotherapy and chemotherapy,and has high clinical application value.
万方数据
维普
