Relationship between DCE-MRI Quantitative Parameters and Benign and Malignant Lesions in Patients with Breast Nodules
Objective To explore the diagnostic value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)for benign and malignant lesions in patients with breast nodules.Methods A retrospective analysis was performed on the clinical data of 74 patients with breast nodules admitted to the hospital between January 2020 and September 2023.All underwent pathological diagnosis and DCE-MRI examination.According to pathological results,patients were divided into benign group and malignant group.The imaging characteristics and quantitative parameters of DCE-MRI[extravascular extracellular space volume fraction(Ve),reflux rate constant(Kep),volume transfer constant(Ktrans)]in the two groups were compared.The value of the above quantitative parameters in the differential diagnosis of benign and malignant breast nodules was determined by ROC analysis and area under ROC curve(AUC).Results In the 74 patients,pathological results showed that there were 48 cases(64.86％)with benign lesions in benign group and 26 cases(35.14％)with malignant lesions in malignant group.There were significant differences in lesion morphology,enhancement modes and TIC types between the two groups(P＜0.05).Ktrans and Kep in malignant group were higher than those in benign group,while Ve was lower than that in benign group(P＜0.05).Taking pathological results as the golden standard,ROC curves were drawn,AUC of Ktrans,Kep and Ve were 0.906,0.867 and 0.645,respectively(P＜0.05).The value of Ktrans and Kep was higher in the differential diagnosis of benign and malignant breast nodules.The sensitivity of Ktrans was the highest(80.77％),and specificity of Kep was the highest(97.92％).Conclusion The expressions of DCE-MRI quantitative parameters Ktrans and Kep are higher in malignant lesions of breast nodules,which have high value in the differential diagnosis of benign and malignant lesions.However,the relationship between Ve and benign and malignant lesions still needs further studv.
Breast NoduleDynamic Contrast-enhanced Magnetic Resonance ImagingQuantitative ParameterDifferential Diagnosis
万方数据
维普
