Objective To explore the diagnostic value of quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)for benign and malignant lesions in patients with breast nodules.Methods A retrospective analysis was performed on the clinical data of 74 patients with breast nodules admitted to the hospital between January 2020 and September 2023.All underwent pathological diagnosis and DCE-MRI examination.According to pathological results,patients were divided into benign group and malignant group.The imaging characteristics and quantitative parameters of DCE-MRI[extravascular extracellular space volume fraction(Ve),reflux rate constant(Kep),volume transfer constant(Ktrans)]in the two groups were compared.The value of the above quantitative parameters in the differential diagnosis of benign and malignant breast nodules was determined by ROC analysis and area under ROC curve(AUC).Results In the 74 patients,pathological results showed that there were 48 cases(64.86％)with benign lesions in benign group and 26 cases(35.14％)with malignant lesions in malignant group.There were significant differences in lesion morphology,enhancement modes and TIC types between the two groups(P＜0.05).Ktrans and Kep in malignant group were higher than those in benign group,while Ve was lower than that in benign group(P＜0.05).Taking pathological results as the golden standard,ROC curves were drawn,AUC of Ktrans,Kep and Ve were 0.906,0.867 and 0.645,respectively(P＜0.05).The value of Ktrans and Kep was higher in the differential diagnosis of benign and malignant breast nodules.The sensitivity of Ktrans was the highest(80.77％),and specificity of Kep was the highest(97.92％).Conclusion The expressions of DCE-MRI quantitative parameters Ktrans and Kep are higher in malignant lesions of breast nodules,which have high value in the differential diagnosis of benign and malignant lesions.However,the relationship between Ve and benign and malignant lesions still needs further studv.
关键词
乳腺结节/磁共振动态增强序列/定量参数/鉴别诊断
Key words
Breast Nodule/Dynamic Contrast-enhanced Magnetic Resonance Imaging/Quantitative Parameter/Differential Diagnosis
维普
万方数据