Application Value of MRI-DWI Combined with Serological Examination in the Diagnosis of Small Hepatocellular Carcinoma
Objective To analyze the clinical application value of magnetic resonance imaging-diffusion weighted imaging(MRI-DWI)combined with serological examination in the diagnosis of small hepatocellular carcinoma(SHCC).Methods A total of 80 patients with SHCC and 71 patients with focal nodular hyperplasia(FNH)in the hospital were retrospectively analyzed between July 2021 and July 2023.All patients underwent MRI-DWI examination to record image characteristics.The signal intensity in MRI-DWI examination,apparent diffusion coefficient(ADC),alpha-fetoprotein(AFP)and carcinoembryonic antigen(CEA)in the two groups were observed and compared.The differential value of signal intensity in MRI-DWI examination,ADC,AFP,CEA and combined detection for SHCC was analyzed by receiver operating characteristic(ROC)curves.The correlation between MRI-DWI parameters,serum indexes and differentiation degree of SHCC was analyzed.Results MRI-DWI showed that there was decreased signal intensity,irregular lesions edge and peripheral tissue invasion in patients with SHCC,while there were obvious center scars and low signal on MRI in patients with FNH.The levels of AFP and CEA in SHCC group were higher than those in FNH group,while signal intensity and ADC were lower those that in FNH group(P＜0.05).The sensitivity and specificity of signal intensity combined with ADC,AFP and CEA were 83.75％and 98.59％,showing high diagnostic value.The signal intensity,ADC,AFP and CEA in high differentiation group were lower than those in low differentiation group(P＜0.05).The signal intensity,ADC and CEA in moderate differentiation group were lower than those in low differentiation group(P＜0.05).Correlation analysis showed that signal intensity in MRI-DWI examination,ADC,AFP and CEA were negatively correlated with the differentiation degree of SHCC(P＜0.05).Conclusion The combined detection of MRI-DWI and serological examination has high diagnostic value for SHCC.With the increase of differentiation degree,signal intensity in MRI-DWI examination,ADC,serum AFP and CEA are decreased in SHCC patients.
Magnetic Resonance Imaging-diffusion Weighted ImagingAlpha-fetoproteinCarcinoembryonic AntigenDifferentiation Degree
万方数据
维普
