The Value of DCE-CT Combined with Histogram Analysis Technique in Differentiating Early Liver Abscess from Intrahepatic Cholangiocarcinoma
Objective To investigate the value of CT enhancement scanning combined with histogram analysis in differentiating early liver abscess and intrahepatic cholangiocarcinoma(ICC)and to validate its diagnostic efficacy.Methods The imaging data of 77 patients suffering from early-stage liver abscess and intrahepatic cholangiocarcinoma who underwent CT enhancement scanning examination in our hospital were collected,and then the histogram data were analyzed by checking the maximum level of the lesion as the region of interest(ROI)using MaZda software.The imaging and histogram parameters with significant differences between groups were included in the binary Logistic regression analysis to evaluate the single-parameter model and the joint model.The value of each parameter was evaluated by using the receiver operating characteristic(ROC)curve,and the area under the curve(AUC)was calculated and validated for diagnostic efficacy.Results In comparison between the early liver abscess group and the ICC group,there was a statistically significant difference between the clinical data and CT features in terms of lesion location,presence of centripetal enhancement/hepatic pericardial notch sign/arterial phase perfusion abnormality,the maximum diameter of the lesion,the difference in enhancement between the arterial and venous phases,and Skewness,and Kurtosis in the histogram parameter(all P＜0.05).Through binary Logistic regression,the analysis yielded lesion site,presence or absence of centripetal enhancement/arterial phase perfusion abnormality,arteriovenous phase enhancement difference,Skewness,and Kurtosis as independent influencing factors.The ROC curve revealed that the joint model had the highest discriminatory efficacy,with an AUC of 0.982 and sensitivity and specificity of 0.905 and 0.971,respectively,which was higher than that of the single-parameter model.Conclusion CT-enhanced scanning combined with histogram analysis is more effective in differentiating early liver abscess and intrahepatic cholangiocarcinoma,which contributes to the accuracy of preoperative diagnosis.
万方数据
维普
