The Effect of Visceral Adipose Tissue on the Accuracy of Preoperative T Staging in Gastric Cancer Patients
Objective To investigated the effect of visceral adipose tissue(VAT)on the accuracy of clinical T staging(cT)in gastric cancer.Methods A retrospective analysis was conducted on the data of patients who underwent gastric cancer resection in our hospital from January 2020 to June 2023.Based on the postoperative pathological results and the degree of consistency between cT and pathological T staging(pT),patients were divided into cT accurate diagnosis group and cT incorrect diagnosis group.The clinical,pathological features,and L2/L3 levels of VAT between two groups of patients were compared.The multivariate Logistic regression analysis was used to identify independent factors that affect the accuracy of cT staging,and construct a column chart to determine the accuracy of cT staging.Results A total of 455 gastric cancer patients included in this study,of which 355(78.02％)had accurate preoperative cT staging,while 100(21.98％)had inaccurate preoperative cT staging.The consistency of ICC analysis between cT staging and pT staging was 0.881(95％Cl:0.691-0.774).The optimal critical value for predicting preoperative cT staging accuracy with VAT was 97.8 cm2.The result of multivariate Logistic regression analysis showed that tumor location(relative to cardiac position,gastric body OR=2.921,P=0.003,gastric antrum OR=1.754,P=0.026),tumor diameter＞3.8 cm(OR=1.253,P＜0.001),and high VAT(＞97.8 cm2)(OR=5.962,P＜0.001)were independent risk factors affecting the accuracy of preoperative cT.The accuracy of the Nomogram chart prediction model for preoperative cT staging of gastric cancer is high,with a C-index of 0.826(95％CI=0.786-0.876).Conclusion VAT,gastric cancer tumor location,and tumor size are independent influencing factors that affect the accuracy of preoperative cT staging.The predicted cT staging accuracy Nomogram chart constructed in this study has high accuracy and has certain application prospects.
万方数据
维普
