Objective To explore dosimetry evaluation of CT-guided iodine-125(125I)radioactive particle in the treatment of lung cancer.Methods A total of 30 patients with advanced lung cancer undergoing CT-guided 125I radioactive particle implantation in interventional department of Cancer Hospital Affiliated to Sun Yat-sen University were enrolled between January 2022 and August 2023.All patients underwent chest enhanced CT scan before surgery,125I radioactive particle implantation pre-operation plan,puncture and 125I radioactive particle implantation(radioactive activity:0.8mCi,prescription dose:120Gy).The number of particles,clinical target volume(CTV),the absorbed dose of 90％target volume(D90),absorbed dose of 100％target volume(D100),percentage of volume covered by 150％prescription dose to target volume(V150),conformal index(Cl),external index(El)and homogeneity index(HI)before and after surgery were compared.The consistency of dosimetry parameters between preoperative plan and postoperative validation was analyzed by Bland-Altman method.Results There was no significant difference in number of particles,CTV,D90 or D100 before and after CT-guided 125I radioactive particle implantation(P＞0.05).After surgery,V150 was decreased(P＜0.05).After surgery,Cl was decreased,while El was increased(P＜0.05).There was no significant difference in HI before and after surgery(P＞0.05).Bland-Altman consistency analysis showed that the consistency of particles number,CTV and HI was good,while consistency of D90,D100,V150,Cl and El was poor before CT-guided 125I radioactive particle implantation.Conclusion The main dosimetry parameters are basically consistent in lung cancer before and after CT-guided 125I radioactive particle implantation,which can better realize preoperative plan and meet clinical demands.
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