Objective To analyze the clinical features and CT imaging findings of 11 cases of primary lung NUT gene related carcinoma(NUT carcinoma).Methods A retrospective analysis was conducted on 11 patients with lung NUT cancer confirmed by immunohistochemistry and pathology at Tangdu Hospital affiliated to Air Force Military Medical University from January 2016 to October 2023.There were 9 males and 2 females,aged 30-65 years,with a median age of 51 years.Collect clinical information,pathological characteristics,and imaging data of patients,and conduct telephone follow-up to understand their treatment history and prognosis.Results The mass was located in 5 cases in the right lung,5 cases in the left lung,and 1 case in the airway.The pulmonary lesions in all 11 patients showed lobular growth,with a maximum diameter of 2.5cm～11.5cm and an average maximum diameter of 5.5cm;Six lesions had uniform density on plain CT scans,five lesions had uneven density,and eight patients showed mild enhancement of the mass on contrast-enhanced scans.There were 10 cases of metastasis,including 9 cases of mediastinal and hilar lymph node metastasis,4 cases of intrapulmonary metastasis(3 cases of ipsilateral lung metastasis,1 case of bilateral intrapulmonary metastasis),4 cases of bone metastasis(3 cases of osteolytic metastasis,1 case of osteogenic metastasis),and 1 case of liver metastasis.All 11 cases of immunohistochemical NUT were positive.5 patients died,of which 3 were untreated and died of multiple organ failure 2 months after onset,1 patient died 2 months after chemotherapy and lobectomy,and 1 patient died 2 months after lobectomy.Six surviving patients were followed up for 1-33 months after treatment.Conclusion NUT cancer is a rare gene related malignant solid tumor in the lungs,which can occur in both lungs.It is characterized by lobulated masses with large volume,uniform or uneven density,mild enhancement on enhanced scans,and often accompanied by multiple lymph node metastases in the hilar and mediastinum,making it more prone to distant metastasis.After receiving early treatment,survival time can be extended.
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