Objective To explore the diagnostic value of multidetector spiral CT combined with serum glucagon-like peptide 1(GLP-1)and type Ⅰ procollagen amino-terminal propeptide(PINP)in the diagnosis of osteoporosis after breast cancer surgery.Methods A total of 152 patients with a history of breast cancer surgery who were admitted to our hospital from January 2021 to January 2023 were divided into osteoporosis group(62 cases)and non-osteoporosis group(90 cases)according to whether osteoporosis occurred after postoperative dual-energy X-ray detection.The patients underwent multi-spiral CT and dual-energy X-ray detection.Enzyme-linked immunosorbent assay was used to detect serum GLP-1 and PIPP levels.The receiver operating characteristic(ROC)curve was used to analyze the critical diagnostic point of serum GLP-1 and PIPP for osteoporosis after breast cancer surgery.A four-grid table was used to analyze the diagnostic value of multidetector spiral CT combined with serum GLP-1 and PIMP in osteoporosis after breast cancer surgery.Results The CT value in the osteoporosis group was significantly lower than that in the non osteoporosis group(P＜0.05).The serum GLP-1 level in the osteoporosis group was obviously lower than that in the non osteoporosis group(P＜0.05),and the PINP level was obviously higher than that in the non osteoporosis group(P＜0.05).The AUC of serum GLP-1 for diagnosis of osteoporosis after breast cancer surgery was 0.842,the AUC of serum PINP for diagnosis of osteoporosis after breast cancer surgery was 0.881,and the AUC of CT value for diagnosis of osteoporosis after breast cancer surgery was 0.889,the AUC of the three combined diagnosis of osteoporosis after breast cancer surgery was 0.971.The accuracy,sensitivity and specificity of multidetector spiral CT in the diagnosis of osteoporosis after breast cancer surgery were 89.47％,91.11％and 87.10％;the accuracy of GLP-1 in the diagnosis of osteoporosis after breast cancer surgery was 84.87％,the sensitivity was 87.78％,and the specificity was 80.65％;the accuracy of PINP in the diagnosis of osteoporosis after breast cancer surgery was 82.89％,the sensitivity was 85.56％,and the specificity was 79.03％;the accuracy,sensitivity and specificity of the combined detection of the three in the diagnosis of osteoporosis after breast cancer surgery were 93.42％,94.44％and 91.94％respectively.Conclusion The decrease of serum GLP-1 level and the increase of PIMP level are related to the occurrence of osteoporosis after breast cancer surgery,and multidetector CT combined with serum GLP-1 and PIMP can improve the diagnostic value of osteoporosis after breast cancer surgery.
关键词
多排螺旋CT/胰高血糖素样肽1/Ⅰ型前胶原氨基端前肽/乳腺癌/骨质疏松症/诊断
Key words
Multidetector Spiral CT/Glucagon-like Peptide 1/Procollagen Type Ⅰ N-terminal Propeptide/Breast Cancer/Osteoporosis/Diagnosis
维普
万方数据