Dynamic Comparison of DCE-MRI for Staging and Diagnosis of Cervical Cancer
Objective To explore the application value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the staging diagnosis of cervical cancer.Methods The study subjects were 240 patients diagnosed with cervical cancer through pathological examination admitted to our hospital from January 2019 to January 2022.All patients received surgical treatment,MRI imaging examination and DCE-MRI examination were performed before and after treatment.At the same time,pathological examinations(including the latest WHO pathological classification)were included in the staging system at a selected time before treatment,ensuring more accurate tumor size in this study.The accuracy of DCE-MRI and pathological examination in staging diagnosis of cervical cancer was observed and compared,as well as the guiding significance of DCE-MRI for patient prognosis.Results Using histopathological examination results as the gold standard,a total of 157 cases were diagnosed in stage Ⅰ to stage Ⅱpatients,and 83 cases were diagnosed in stage Ⅲ to stage Ⅳ.The accuracy of stage diagnosis in DCE-MRI cases was 96.67％(232/240),and 8 cases were not detected.There was no significant difference between stage diagnosis results and histopathological results(P＞0.05).The sensitivity and specificity of DCE-MRI in evaluating the staging of stage Ⅲ-Ⅳ cervical cancer were 91.57％(76/83)and 99.36％(156/157),respectively.Observing the pharmacokinetic parameters of DCE-MRI in patients with different degrees of differentiation and stages,the quantitative parameters of volume transfer constant(Ktrans),rate constant(Kep),and extracellular extracellular space leakage space(Ve)in patients with high differentiation of cancer cells were lower than those in patients with low and medium differentiation(P＜0.05);The levels of Ktrans,kep,and Ve in patients with stage Ⅲ-Ⅳ were higher than those in patients with stage Ⅰ-Ⅱ(P＜0.05).During the follow-up process,80 patients(33.33％)relapsed after discharge,and the levels of Ktrans,kep,and Ve in relapsed patients were higher than those in non relapsed patients(P＜0.05).Conclusion DCE-MRI has high accuracy in staging diagnosis of cervical cancer patients,can assist in clinical prediction of patient prognosis,and has high application value.
Dynamic Contrast-enhanced Magnetic Resonance Imaging TechnologyCervical CancerStaging DiagnosisPrognosis
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维普
