Feasibility of Quantitative Synthetic MRI for Discriminating Endometrial Carcinoma from Peripheral Myometrium
Objective To investigate the feasibility of using T1,T2,and proton density(PD)derived from synthetic MRI for discriminating endometrial carcinoma(ECa)from normal appearing peripheral myometrium(nPM)of ECa patients.Methods 16 patients with ECa underwent both conventional pelvic MRI and synthetic MRI were included in our study.Regions of interest(ROI)were placed over ECa and nPM based on synthetic T2-weighted images.Independent sample t-test was used to evaluate the differences of T1,T2,and PD values between ECa and nPM.Receiver operating characteristic(ROC)curve was used to assess the diagnostic effectiveness of each quantitative parameter in differentiating ECa from nPM.Results T1,T2 values of nPM were significantly lower than that of Eca(P=0.001,P＜0.001,respectively)and no significant difference of PD value was found between Eca and nPM(P=0.177).In differentiating Eca from nPM,the Area Under the Curve(AUC)of T2 value(AUC=1.000)was significantly higher than that of T1(AUC=0.831)and PD(AUC=0.651)values(P=0.028 and 0.002,respectively).No significant differences were demonstrated between the AUC of T1 and PD values(P=0.153).The combination of T1,T2,and PD values showed a significantly higher diagnostic performance compared with T1 or PD values in discriminating Eca from nPM(P=0.028 and 0.002,respectively).Conclusion Synthetic MRI can be potentially used as a new method for quantification of T1,T2,and PD values of normal uterine tissues and Eca.T2 value was more useful than T1 and PD values in discriminating Eca from nPM of cancer patients.
Synthetic Magnetic Resonance ImagingEndometrial CarcinomaUterusRelaxation TimeProton Density
万方数据
维普
