Objective To investigate the clinical characteristics and prognosis of acute erythroleukemia(AEL)in children.Methods A retrospective analysis was conducted on the clinical data,treatment,and prognosis of 8 children with AEL treated at the First Affiliated Hospital of Zhengzhou University from January 2013 to December 2023.Results Among the 7 patients with complete bone marrow morphological analysis,4 exhibited trilineage dysplasia,with a 100%incidence of erythroid dysplasia(7/7),a 71%incidence of myeloid dysplasia(5/7),and a 57%incidence of megakaryocytic dysplasia(4/7).Immunophenotyping revealed that myeloid antigens were primarily expressed as CD13,CD33,CD117,CD38,and CD123,with 4 cases expressing erythroid antigens CD71 and 2 cases expressing CD235a.Chromosomal analysis indicated that 2 cases presented with abnormal karyotypes,including+8 in one case and+4 accompanied by+6 in another;no complex karyotypes were observed.Genetic abnormalities were detected in 4 cases,with fusion genes including one case each of dup MLL positive and EVI1 positive,as well as mutations involving KRAS,NRAS,WT1,and UBTF.Seven patients received chemotherapy,with 6 achieving remission after one course of treatment;2 underwent hematopoietic stem cell transplantation,and all had disease-free survival.Follow-up(median follow-up time of 6 months)showed that only 3 patients survived(2 cases after hematopoietic stem cell transplantation and 1 case during treatment).Conclusions Children with AEL have unique clinical and biological characteristics,exhibit poor treatment response,and have a poor prognosis;however,hematopoietic stem cell transplantation may improve overall survival rates.
维普
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