Investigation on thyroid function of pregnant women in areas with different iodine nutrition levels in Yunnan Province
Objective To understand the thyroid function status of pregnant women in areas with different urinary iodine levels(median urinary iodine:100-149,150-250 μg/L)in Yunnan Province,so as to provide scientific basis for establishing iodine nutrition evaluation standards applicable to pregnant women in China.Methods A cross-sectional study was conducted in Zhenxiong County of Zhaotong City and Jianshui County of Honghe Region from June to December 2021.Each county selected one survey point in urban and rural areas respectively,and at least 100 pregnant women were surveyed at each survey point.The urine samples and fasting blood samples of the subjects were collected to detect the urine iodine and thyroid function.Thyroid B-ultrasound examination was carried out to detect thyroid volume and nodules.Results A total of 403 pregnant women were investigated.The median urinary iodine in Jianshui County and Zhenxiong County was 154.66(n=206),117.67 μg/L(n=197),respectively,the difference of urinary iodine level was statistically significant(Z=-4.918,P＜0.05).The thyroid function(TSH,TT3,TT4,FT3,FT4)levels in Jianshui and Zhenxiong counties were compared according to the pregnancy stage.Except for the difference of FT4(median:18.94 and 17.10 pmol/L in Jianshui and Zhenxiong counties respectively)in the early pregnancy stage(Z=-2.018,P＜0.05),there was no statistical difference in other indicators.The detection rates of hypothyroidism,hyper-thyroidism,sub-hypothyroidism,sub-hyperthyroidism and low FT4 in the two counties were statistically analyzed.The detection rates in Jianshui County were 0,0.49％,1.46％,2.91％and 3.40％respectively,and those in Zhenxiong County were 1.02％,2.03％,4.57％,2.03％and 4.06％respectively.The total abnormal rate of thyroid function was 8.25％in Jianshui County and 13.71％in Zhenxiong County,with no statistical difference(x2=3.079,P＞0.05).The detection rate of thyroid nodules was 14.56％and 12.18％respectively,with no statistical difference(x2=0.492,P＞0.05).The goiter rate was 0 and 0.51％respectively,which was at a low level.Conclusion The results of this survey showed that there was no difference in thyroid function of pregnant women between the two regions of median urinary iodine(between 100-149 and 150-250 μg/L).It is suggested to expand the sample size and strengthen relevant research and explore the standard of median urinary iodine applicable to pregnant women in China.
Pregnant womenUrine iodineIodine nutritionThyroid function
NETL
NSTL
万方数据
