广西沿海地区妇女血清碘医学参考值范围的建立
Establishment of a medical reference range of serum iodine in women in coastal areas of Guangxi
王芬芬 1廖敏 1陆皓泉 1罗兰英1
作者信息
- 1. 广西壮族自治区疾病预防控制中心,广西南宁 530028
- 折叠
摘要
目的 建立广西沿海地区妇女血清碘医学参考值范围,为孕妇个体碘营养评价提供参考依据.方法 2020年1-12月,选择广西沿海4个县区的县医院作为调查点,每个调查点选取至少60名健康孕妇和60名健康非妊娠妇女作为调查对象.采集所有调查对象的尿样、血样,检测尿碘、血清碘含量及甲功指标[促甲状腺激素(TSH)、甲状腺球蛋白(Tg)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb)]水平.采用百分位数法建立沿海地区妇女血清碘95％医学参考值范围,并采用Pearson相关分析进行沿海地区妇女血清碘与甲功指标的相关性分析.结果 共检测241例孕妇,尿碘中位数为148.00 μg/L,处于碘缺乏状态(＜150 μg/L),血清碘为(64.16±22.51)μg/L),孕妇血清碘95％医学参考值范围初步定为31.42～103.00 μg/L;检测242例非妊娠妇女,尿碘中位数为179.80 μg/L,处于碘适宜水平(100～199 μg/L),血清碘为(52.21±25.05)μg/L,非妊娠妇女血清碘95％医学参考值范围初步定为23.92～102.85 µg/L.孕妇尿碘中位数低于非妊娠妇女尿碘中位数(148.00 μg/L比179.80 μg/L),血清碘高于非妊娠妇女血清碘(64.16 μg/L比52.21 µg/L),差异均有统计学意义(Z=-3.205、-6.697,P均＜0.001).相关性分析显示:孕妇血清碘与FT4水平呈正相关(r=0.40,P＜0.001),与其余甲功指标均未见相关性(P均＞0.05);非妊娠妇女血清碘与甲功指标均未见相关性(P＞0.05).结论 本研究首次建立了广西沿海地区妇女血清碘医学参考值范围,可为妇女个体碘营养评价提供参考依据.
Abstract
Objective To establish of a medical reference range of serum iodine in women in coastal areas of Guangxi,so as to provide the evidence for judgment of individual iodine nutrition in pregnant women.Methods From January to December 2020,four county hospitals along the coast of Guangxi were selected,at least 60 healthy pregnant women and 60 healthy non-pregnant women were selected as survey subjects in each investigation site.Urine and blood samples were collected to detect urinary iodine,serum iodine and thyroid function indexes[thyroid stimulating hormone(TSH),thyroglobulin(Tg),free triiodothyronine(FT3),free thyroxine(FT4),thyroglobulin antibody(TgAb)and thyroid peroxidase antibody(TPOAb)]levels.The percentile method was used to establish the 95％medical reference range of serum iodine in women in coastal areas,and Pearson correlation analysis was used to analyze the correlation between serum iodine and thyroid function indexes in women in coastal areas.Results A total of 241 pregnant women were examined,and the median urinary iodine was 148.00 μg/L,which was at the iodine deficiency level(＜150 μg/L);serum iodine was(64.16±22.51)μg/L,and the 95％medical reference range of serum iodine in pregnant women was preliminarily formulated as 31.42-103.00 μg/L.A total of 242 non-pregnant women were examined,and the median urinary iodine was 179.80 μg/L,which was at the appropriate level(100-199 μg/L);serum iodine was(52.21±25.05)μg/L,and the 95％medical reference range of serum iodine in pregnant women was preliminarily formulated as 23.92-102.85 μg/L.The median urinary iodine of pregnant women was lower than non-pregnant women(148.00 μg/L vs 179.80 μg/L),and the serum iodine of pregnant women was higher than non-pregnant women(64.16 μg/L vs 52.21 μg/L),the difference was statistically significant(Z=-3.205,-6.697,P＜0.001).The correlation analysis showed that serum iodine of pregnant women was positively correlated with FT4 level(r=0.40,P＜0.001),but not with other thyroid function indexes(P＞0.05).The serum iodine of non-pregnant women was not correlated with thyroid function indexes(P＞0.05).Conclusion The medical reference value range of serum iodine in women in coastal areas of Guangxi is firstly established,which provides a basis for judgment of individual iodine nutrition in women.
关键词
沿海地区/孕妇/血清/碘Key words
Coastal areas/Pregnant women/Serum/Iodine引用本文复制引用
基金项目
广西卫生健康委员会自筹经费科研课题(Z20200766)
出版年
2024
NETL
NSTL
万方数据