Research Progress on the Resistance of Avian Escherichia coli to Fuoroquinolones
Fluoroquinolones(FQs)are one of the antibacterial agents widely used in poultry farming.However,in recent years,the overuse of FQs in livestock and poultry industry has led to production of drug-resistant strains of bacteria,and bacterial resistance to such drugs has become more and more serious,with increasing resistant spectrum;the resistance mechanism is also becoming more and more complex,mainly through four mechanisms of action:chromosome-mediated,exocytosis system-mediated,membrane permeability reduction and plasmid-mediated;the technologies detecting the resistance has been constantly developed,including drug sensitivity test,gene chip,PCR,fluorescence in situ hybridization,whole genome sequencing,metagenomic sequencing,etc.In view of the increasingly severe status of bacterial resistance,it was necessary to vigorously implement monitoring of bacterial resistance,develop new types of drugs such as traditional Chinese medicine and quinolone hybrids,strengthen education and publicity,improve monitoring and early warning system,guide reasonable administration,implement"reducing antibiotics and replacing antibiotics"and other comprehensive control measures,and actively response to all issues caused by bacterial resistance.In the paper,taking 4 common fluoroquinolones including enrofloxacin,ciprofloxacin,oxfloxacin and nalidixic acid as examples,research progress on the resistance of Escherichia coli of avian origin to such drugs as well as on its action mechanisms,detection methods and control measures was reviewed,with a view to providing a basis for safeguarding the safety of food-producing animals and public health.
国家科技期刊平台
NSTL
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