我国牛源金黄色葡萄球菌耐药情况及防控研究进展
Drug Resistance of Bovine Staphylococcus aureus and Research Progress on Its Control Strategies in China
胡方圆 1王琳 2刘耀蓬 1宋时萍 2郭皖露 3刘娜 2高玉斌 2王娟 2黄秀梅 2赵建梅 2刘俊辉 2曲志娜 2王君玮2
作者信息
- 1. 中国动物卫生与流行病学中心,农业农村部畜禽产品质量安全风险评估实验室,山东青岛 266032;山西农业大学动物医学院,山西晋中 030801
- 2. 中国动物卫生与流行病学中心,农业农村部畜禽产品质量安全风险评估实验室,山东青岛 266032
- 3. 中国动物卫生与流行病学中心,农业农村部畜禽产品质量安全风险评估实验室,山东青岛 266032;青岛农业大学动物医学院,山东青岛 266109
- 折叠
摘要
金黄色葡萄球菌是导致奶牛乳腺炎的常见病因之一,而使用抗生素是预防和治疗其感染的唯一有效方法.但是,在长期面对抗生素的选择压力下,金黄色葡萄球菌对多种药物产生了耐药性,也使动物成为耐药基因的储存库,对食品安全和人类健康构成威胁.通过分析国内牛源金黄色葡萄球菌相关研究发现:我国牛源金黄色葡萄球菌耐药率不断提高,多重耐药程度不断加重,尤其北方高纬度地区面临更为严峻的耐药形势;我国牛源金黄色葡萄球菌具有丰富的分子流行特征,其中ST9、ST97、ST398 为优势分型且分布广泛,MRSA SCCmec Ⅻ、SCCmec Ⅲ和SCCmec Ⅳ 3种分型近年来呈现扩散分布趋势;为解决金黄色葡萄球菌耐药问题,国内正在研究中药制剂、噬菌体、益生菌、抗菌肽等4种抗生素代替方法,这些制剂具有较好的开发前景.本文综述了我国牛源金黄色葡萄球菌的耐药情况以及防控技术研究进展,可为牛源金黄色葡萄球菌耐药防治提供参考.
Abstract
Staphylococcus aureus(S.aureus)is one of the common causes of cow mastitis,which could be effectively prevented and treated only by antibiotics.It,however,is resistant to a variety of antibiotics due to prolonged use of antibiotics,and makes animals become the reservoir of drug-resistant genes,posing a threat to food safety and human health.It is found that,based on domestic relevant researches on bovine S.aureus,the drug resistance rate of bovine S.aureus has been increasing in China with worsening multi-drug resistance,especially in the northern high-latitude regions;rich molecular epidemiological characteristics are found,dominated by ST9,ST97 and ST398 types that are widely distributed,MRSA SCCmec Ⅻ,SCCmec Ⅲ and SCCmec Ⅳ tend to spread diffusively;antibiotic substitutions with a better prospect including Chinese medicinal preparation,phage,probiotics and antimicrobial peptide are under development to solve the drug resistance of S.aureus.Here,the drug resistance of bovine S.aureus and the research progress of its prevention and control technologies in China were reviewed,supporting future prevention and control of such drug resistance.
关键词
金黄色葡萄球菌/抗微生物药物耐药性/耐药防控Key words
S.aureus/anti-microbial resistance/prevention and control of drug resistance引用本文复制引用
基金项目
国家重点研发计划项目(2022YFC2303900)
中国动物卫生与流行病学中心创新基金项目(DW2021018)
出版年
2024
国家科技期刊平台
NSTL
万方数据