Research Progress on Tuberculosis Diagnostic Biomarkers
Tuberculosis(TB)is caused by Mycobacterium tuberculosis complex(MTBC),posing a threat to human and animal health all over the world.MTBC members have highly similar genomic sequence,resulting in difficulty in identification.But current diagnostic biomarkers are limited in early diagnosis of tuberculosis,distinguishing latent Mycobacterium tuberculosis infection from active tuberculosis status,evaluation on treatment efficacy,etc.With the development of molecular biology technologies and continuous clinical researches,more potential TB diagnostic biomarkers have been discovered.Here,the research progress and application of TB diagnostic biomarkers including DNA,RNA,lipoarabinomannan(LAM),proteins,cytokines,metabolites and others were summarized from the aspects of TB pathogens and hosts,with a view to providing a basis and direction for application of TB diagnostic biomarkers and development of relevant diagnosis technologies and products.