羊布鲁氏菌病生物安全相关风险因素及群流行率Meta分析
Meta-analysis on Biosafety Risk Factors and Herd Prevalence of Ovine Brucellosis
王新 1张涛 1刘健 2张靖飞 1刘贺 3冯鹏 1高娟 1吴萌萌 1石龙飞 1白东宁 1李俊生 4吴洪涛 5薛佳佳 1李扬帆 1徐琨6
作者信息
- 1. 西安市动物疫病预防控制中心,陕西 西安 710061
- 2. 上海市动物疫病预防控制中心,上海 201103
- 3. 抚顺市动物疫病预防控制中心,辽宁抚顺 113013
- 4. 西安市灞桥区动物疫病预防控制中心,陕西 西安 710024
- 5. 辽宁省农业发展服务中心,辽宁 沈阳 111200
- 6. 西安市疾病预防控制中心,陕西 西安 710054
- 折叠
摘要
为对羊布鲁氏菌病(简称布病)传播相关生物安全风险因素及其真实群流行率进行合并定量评价分析,从中英文数据库中筛选出符合条件的横断面研究及病例对照研究文献,使用二分类变量Meta分析定量评价羊布病传播风险因素,使用单组率Meta分析评价羊布病真实群体流行率,并进行文献敏感性分析.羊布病风险因素评价纳入 5 篇文献,从中筛选出 8 个风险因素,真实群流行率分析纳入 8 篇文献.分析认为:外购混养是最显著的羊布病传播风险因素(P＜0.05),合并OR值为11.88,其次为1年内引进新羊(OR=4.80)、产羔地未消毒(OR=4.40)及共用/交换种公羊(OR=3.02),P值均＜0.05;1 年内有经纪人进羊圈(OR=4.21)、场区门口不消毒(OR=2.20)、流产母羊不处理或不进行治疗(OR=2.06)、与其他动物混养(OR=1.09)是影响羊布病传播的潜在风险因素(P＞0.05).北方地区羊布病真实群流行率为 22%(95%CI:5%～39%),南方地区为0～3%(95%CI:0～6%),合并流行率为11%(95%CI:6%～17%).提示应加强羊场生物安全风险管理,重点控制羊布病传播风险因素,关注潜在风险因素,加强羊只调运监管,采取针对性防控策略,推进畜间布病防控净化工作.
Abstract
In order to comprehensively and quantitatively evaluate biosafety risk factors related to ovine brucellosis transmission and its herd true prevalence(TPh),articles on cross-sectional and case-control studies were selected from databases both in Chinese and English languages,the risk factors of ovine brucellosis transmission was quantitatively evaluated using dichotomous variable Meta-analysis,and the TPh of ovine brucellosis was evaluated using single proportion Meta-analysis,followed by article sensitivity analysis.Five articles were included in the evaluation of ovine brucellosis risk factors,from which 8 risk factors were selected,and 8 articles were considered in the TPh.The most significant risk factor spreading brucellosis was mixed feeding with outsourced sheep,with a combined OR value of 11.88,then were the sheep introduced within one-year(OR=4.80),non-disinfection on lambing premises(OR=4.40)and shared/exchanged stud rams(OR=3.02),P＜0.05;and the potential risk factors(P＞0.05)included brokers entering sheep pens within one year(OR=4.21),non-disinfection at entrance to the farm(OR=2.20),untreated aborted ewes(OR=2.06)and mixing with other animals(OR=1.09).The TPh was 22%(95%CI:5%-39%)in northern region,and 0-3%(95%CI:0-6%)in southern region,the combined prevalence rate was 11%(95%CI:6%-17%).In conclusion,it was recommended to strengthen biosafety risk management on sheep farms with a priority to control of the risk factors of ovine brucellosis transmission and concern about potential risk factors,to improve supervision over sheep transportation,to implement targeted prevention and control strategies,and to facilitate prevention and purification of Brucellosis among animals.
关键词
布鲁氏菌病/风险因素/生物安全/Meta分析/羊Key words
brucellosis/risk factor/Meta-analysis/sheep引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据