Evolutionary Mechanism of Senecavirus A and Its Impact on Vaccine and Antiviral Drug Development
Senecavirus disease is a viral infectious disease caused by Senecavirus A(SVA),primarily affecting pigs.As a transboundary animal disease virus,SVA has made a significant impact on pig industry in several countries since it was firstly found.SVA presented significant genetic diversity caused by its wide prevalence in pig herds,unique replication mechanism and frequent recombination and variation among different strains,which made it rapidly adapt to host immune pressures and other environmental changes,posing a new challenge to the development of vaccines and antiviral drugs.In the paper,the key factors influencing SVA evolution were analyzed,including codon use preference,positive selection,negative selection,internal ribosome entry site(IRES)region variation and genomic RNA recombination,the specific impact of low-fidelity RNA-dependent RNA polymerase(RdRp)on vaccine development was analyzed,and the updates in antiviral drug researches were systematically summarized,aiming to provide solid theoretical basis for the development of more accurate and effective preventive measures and treatment plans against the disease,and thus to response to the threat of continuous transmission imposed by SVA,protect the health of pig herds,and to promote the stable development of pig industry.
SVApigevolution mechanismvaccine developmentantiviral drug
万方数据
维普
