Genomic Characteristics of Different Avian-origin Coronaviruses
Coronavirus(CoV)is a highly infectious RNA virus that is widely distributed in nature and prone to genetic recombination and mutation,indicating a great significance of its genomic characterization to develop detection techniques,explore viral action mechanism and to produce novel vaccines.CoV was driven to evolve by its error-prone RNA polymerase and genome recombination mutation due to its large genome.To be specific,avian infectious bronchitis virus(IBV)was genetically diverse with a typical CoV morphology,and could rapidly evolve into dozens of serotypes driven by natural selection and human intervention;for turkey coronavirus(TCoV),the genomes other than the fibrillar gene were closely related to IBV,and mainly responsible for host transfer from chickens to turkeys;for duck coronavirus(DuCoV),the genome structure was similar to that of IBV,indicating a potential for genetic recombination with IBV;for goose coronavirus(GCoV),the genome was longer by approximately 1 000 nt compared to IBV,indicating certain difference from the conventional avian-origin CoV;the nucleotide sequence of CoV in wild birds was similar to that of DuCoV isolated in China,and its genome was with typical CoV characteristics;compared with IBV and DuCoV,base mutation,insertion and deletion appeared in 7 conserved regions of pigeon CoV.In this paper,the genome structure and classification of CoV were briefly described,and the genomic characteristics of IBV,TCoV,and other avian-origin CoV(such as waterfowls and wild birds)were reviewed,with a view to guiding future researches on the biological characteristics and differential detection techniques of CoV.
万方数据
维普
